Albright Joslyn M, Dunn Robert C, Shults Jill A, Boe Devin M, Afshar Majid, Kovacs Elizabeth J
1 Department of Surgery, Loyola University Chicago Health Sciences Campus , Maywood, Illinois.
2 Burn and Shock Trauma Research Institute, Loyola University Chicago Health Sciences Campus , Maywood, Illinois.
Antioxid Redox Signal. 2016 Nov 20;25(15):805-815. doi: 10.1089/ars.2016.6691. Epub 2016 Aug 3.
With the growing population of baby boomers, there is a great need to determine the effects of advanced age on the function of the immune system. Recent Advances: It is universally accepted that advanced age is associated with a chronic low-grade inflammatory state that is referred to as inflamm-aging, which alters the function of both immune and nonimmune cells. Mononuclear phagocytes play a central role in both the initiation and resolution of inflammation in multiple organ systems and exhibit marked changes in phenotype and function in response to environmental cues, including the low levels of pro-inflammatory mediators seen in the aged.
Although we know a great deal about the function of immune cells in young adults and there is a growing body of literature focusing on aging of the adaptive immune system, much less is known about the impact of age on innate immunity and the critical role of the mononuclear phagocytes in this process.
In this article, there is a focus on the tissue-specific monocyte and macrophage subsets and how they are altered in the aged milieu, with the hope that this compilation of observations will spark an expansion of research in the field. Antioxid. Redox Signal. 25, 805-815.
随着婴儿潮一代人口的不断增加，迫切需要确定高龄对免疫系统功能的影响。最新进展：人们普遍认为，高龄与一种被称为炎症衰老的慢性低度炎症状态相关，这种状态会改变免疫细胞和非免疫细胞的功能。单核吞噬细胞在多个器官系统炎症的起始和消退过程中都起着核心作用，并且会根据环境信号（包括老年人中所见的低水平促炎介质）在表型和功能上表现出显著变化。
尽管我们对年轻成年人免疫细胞的功能了解很多，并且关注适应性免疫系统衰老的文献也越来越多，但对于年龄对固有免疫的影响以及单核吞噬细胞在此过程中的关键作用却知之甚少。
在本文中，重点关注组织特异性单核细胞和巨噬细胞亚群以及它们在老年环境中的变化，希望这些观察结果的汇总能够激发该领域研究的扩展。《抗氧化. 氧化还原信号》25, 805 - 815。
