Zarins Andrea, Smith Douglas, Fahim Simone
Dermatology Division, Department of Medicine, University of Ottawa, Ottawa, Ontario, Canada
Rheumatology Division, Department of Medicine, The Ottawa Hospital-Riverside Campus, University of Ottawa, Ottawa, Ontario, Canada.
J Cutan Med Surg. 2016 Nov;20(6):579-581. doi: 10.1177/1203475416658001. Epub 2016 Jun 29.
The association between lymphoproliferative malignancies and autoimmune rheumatological diseases, such as systemic lupus erythematosus (SLE), remains of great interest. It is known that individuals with immune dysregulation also have an increased risk of lymphoma.
To report a case of primary cutaneous diffuse large B-cell lymphoma of the leg type associated with longstanding SLE, as well as to review the literature for similar cases.
A PubMed search was done using the following search terms: lupus and B-cell lymphoma.
Although several studies show that non-Hodgkin lymphoma is significantly increased in SLE, there is currently no literature reporting specifically on the risk of primary cutaneous lymphomas in patients with SLE.
Our report highlights the possibility that patients with autoimmune disease are at increased risk of not only the classic forms of non-Hodgkin lymphoma but also primary cutaneous B-cell lymphomas.
淋巴增生性恶性肿瘤与自身免疫性风湿性疾病（如系统性红斑狼疮，SLE）之间的关联一直备受关注。已知免疫调节异常的个体患淋巴瘤的风险也会增加。
报告一例与长期SLE相关的腿部原发性皮肤弥漫性大B细胞淋巴瘤病例，并回顾文献中类似病例。
使用以下检索词在PubMed上进行检索：狼疮和B细胞淋巴瘤。
尽管多项研究表明SLE患者中非霍奇金淋巴瘤显著增加，但目前尚无专门报道SLE患者原发性皮肤淋巴瘤风险的文献。
我们的报告强调了自身免疫性疾病患者不仅患经典形式非霍奇金淋巴瘤的风险增加，而且患原发性皮肤B细胞淋巴瘤的风险也增加的可能性。
