Regulation and function of the SLC38A3/SNAT3 glutamine transporter.
作者信息
Rubio-Aliaga Isabel, Wagner Carsten A
机构信息
a Institute of Physiology, the National Center for Competence in Research NCCR Kidney, University of Zurich , Zurich , Switzerland.
出版信息
Channels (Austin). 2016 Nov;10(6):440-52. doi: 10.1080/19336950.2016.1207024. Epub 2016 Jun 30.
Abstract
摘要
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Cell. 2016 Mar 24;165(1):153-164. doi: 10.1016/j.cell.2016.02.035. Epub 2016 Mar 10.
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Glutamine transporters in mammalian cells and their functions in physiology and cancer.哺乳动物细胞中的谷氨酰胺转运体及其在生理和癌症中的功能。
Biochim Biophys Acta. 2016 Oct;1863(10):2531-9. doi: 10.1016/j.bbamcr.2015.12.017. Epub 2015 Dec 24.
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Loss of function mutation of the Slc38a3 glutamine transporter reveals its critical role for amino acid metabolism in the liver, brain, and kidney.Slc38a3谷氨酰胺转运体的功能丧失突变揭示了其在肝脏、大脑和肾脏氨基酸代谢中的关键作用。
Pflugers Arch. 2016 Feb;468(2):213-27. doi: 10.1007/s00424-015-1742-0. Epub 2015 Oct 21.
4
Sestrin2 is a leucine sensor for the mTORC1 pathway.Sestrin2是mTORC1信号通路的亮氨酸传感器。
Science. 2016 Jan 1;351(6268):43-8. doi: 10.1126/science.aab2674. Epub 2015 Oct 8.
5
System N transporters are critical for glutamine release and modulate metabolic fluxes of glucose and acetate in cultured cortical astrocytes: changes induced by ammonia.系统N转运体对谷氨酰胺释放至关重要，并调节培养的皮质星形胶质细胞中葡萄糖和乙酸盐的代谢通量：氨诱导的变化。
J Neurochem. 2016 Jan;136(2):329-38. doi: 10.1111/jnc.13376. Epub 2015 Nov 10.
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Autophagy. 2016 Jun 2;12(6):1061-2. doi: 10.1080/15548627.2015.1091143. Epub 2015 Oct 2.
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A hepatic amino acid/mTOR/S6K-dependent signalling pathway modulates systemic lipid metabolism via neuronal signals.一条肝脏氨基酸/哺乳动物雷帕霉素靶蛋白/核糖体蛋白S6激酶依赖性信号通路通过神经元信号调节全身脂质代谢。
Nat Commun. 2015 Aug 13;6:7940. doi: 10.1038/ncomms8940.
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Metabolism. Lysosomal amino acid transporter SLC38A9 signals arginine sufficiency to mTORC1.代谢。溶酶体氨基酸转运蛋白SLC38A9向mTORC1发出精氨酸充足的信号。
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Nephrol Dial Transplant. 2015 May;30(5):770-81. doi: 10.1093/ndt/gfu384. Epub 2014 Dec 18.
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Transport of L-glutamine, L-alanine, L-arginine and L-histidine by the neuron-specific Slc38a8 (SNAT8) in CNS.神经特异性溶质载体家族 38 成员 8（Slc38a8，SNAT8）介导中枢神经系统中 L-谷氨酰胺、L-丙氨酸、L-精氨酸和 L-组氨酸的转运。
J Mol Biol. 2015 Mar 27;427(6 Pt B):1495-1512. doi: 10.1016/j.jmb.2014.10.016. Epub 2014 Oct 30.
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