钯催化含半胱氨酸分子在室温下的化学选择性和生物相容性官能化反应。
Palladium-Catalyzed Chemoselective and Biocompatible Functionalization of Cysteine-Containing Molecules at Room Temperature.
作者信息
Al-Shuaeeb Riyadh Ahmed Atto, Kolodych Sergii, Koniev Oleksandr, Delacroix Sébastien, Erb Stéphane, Nicolaÿ Stéphanie, Cintrat Jean-Christophe, Brion Jean-Daniel, Cianférani Sarah, Alami Mouâd, Wagner Alain, Messaoudi Samir
机构信息
BioCIS, Equipe Labellisée Ligue Contre le Cancer, Univ. Paris-Sud, CNRS, University Paris-Saclay, 92296, Châtenay-Malabry, France.
Syndivia SAS, 650 Boulevard Gonthier d'Andernach, 67400, Illkirch, France.
出版信息
Chemistry. 2016 Aug 1;22(32):11365-70. doi: 10.1002/chem.201602277. Epub 2016 Jun 30.
The third generation of aminobiphenyl palladacycle pre-catalyst "G3-Xantphos" enables functionalization of peptides containing cysteine in high yields. The conjugation (bioconjugation) occurs chemoselectively at room temperature under biocompatible conditions. Extension of the method to protein functionalization allows selective bioconjugation of the trastuzumab antibody.
第三代氨基联苯钯环前催化剂“G3-Xantphos”能够以高产率实现含半胱氨酸肽的功能化。这种共轭（生物共轭）在室温下的生物相容性条件下具有化学选择性地发生。将该方法扩展到蛋白质功能化可实现曲妥珠单抗抗体的选择性生物共轭。
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