Choi Seong-Woo, Kweon Sun-Seog, Lee Young-Hoon, Ryu So-Yeon, Choi Jin-Su, Rhee Jung-Ae, Nam Hae-Sung, Jeong Seul-Ki, Park Kyeong-Soo, Kim Hee Nam, Shin Min-Ho
Department of Preventive Medicine, Chosun University Medical School, 309, Pilmun-daero, Dong-gu, Gwangju 501-759, Republic of Korea.
Department of Preventive Medicine, Chonnam National University Medical School, 160, Baekseo-ro, Dong-gu, Gwangju 501-746, Republic of Korea.
PLoS One. 2016 Jun 30;11(6):e0158764. doi: 10.1371/journal.pone.0158764. eCollection 2016.
In type 2 diabetic patients, the relationships between 25-hydroxyvitamin D and parathyroid hormone levels, and glycemic control, remain unclear. We evaluated associations between 25-hydroxyvitamin D, parathyroid hormone, and hemoglobin A1c levels after adjusting for other covariates, including log transformed 25-hydroxyvitamin D levels and log transformed parathyroid hormone levels, in Korean patients with type 2 diabetes. In total, 1,175 patients with type 2 diabetes were selected from 8,857 individuals who completed the baseline survey of the Dong-gu study, conducted in Korea from 2007 to 2010. After adjusting for other covariates, we found that the mean hemoglobin A1c level was inversely associated with the 25-hydroxyvitamin D level (Q1: 7.47% [7.30-7.63], Q2: 7.25% [7.09-7.40], Q3: 7.17% [7.02-7.32], Q4: 7.19% [7.02-7.35]; p for trend = 0.021, p for between groups = 0.050) and the parathyroid hormone level (Q1: 7.35% [7.19-7.51], Q2: 7.34% [7.19-7.50], Q3: 7.28% [7.13-7.43], Q4: 7.09% [6.94-7.24]; p for trend = 0.022, p for between groups = 0.048). However, the mean fasting glucose level was not associated with either the 25-hydroxyvitamin D or parathyroid hormone level. In conclusion, inverse associations were evident between hemoglobin A1c, 25-hydroxyvitamin D and parathyroid hormone levels in Korean patients with type 2 diabetes. The associations remained significant after adjusting for other covariates, including the log transformed 25-hydroxyvitamin D levels and log transformed parathyroid hormone levels.
在2型糖尿病患者中，25-羟维生素D与甲状旁腺激素水平以及血糖控制之间的关系仍不明确。我们在调整了包括对数转换后的25-羟维生素D水平和对数转换后的甲状旁腺激素水平等其他协变量后，评估了韩国2型糖尿病患者中25-羟维生素D、甲状旁腺激素和糖化血红蛋白水平之间的关联。总共从2007年至2010年在韩国进行的东古研究基线调查的8857名个体中选取了1175例2型糖尿病患者。在调整其他协变量后，我们发现糖化血红蛋白平均水平与25-羟维生素D水平呈负相关（第一四分位数：7.47% [7.30 - 7.63]，第二四分位数：7.25% [7.09 - 7.40]，第三四分位数：7.17% [7.02 - 7.32]，第四四分位数：7.19% [7.02 - 7.35]；趋势p值 = 0.021，组间p值 = 0.050）以及与甲状旁腺激素水平呈负相关（第一四分位数：7.35% [7.19 - 7.51]，第二四分位数：7.34% [7.19 - 7.50]，第三四分位数：7.28% [7.13 - 7.43]，第四四分位数：7.09% [6.94 - 7.24]；趋势p值 = 0.022，组间p值 = 0.048）。然而，空腹血糖平均水平与25-羟维生素D或甲状旁腺激素水平均无关联。总之，在韩国2型糖尿病患者中，糖化血红蛋白、25-羟维生素D和甲状旁腺激素水平之间存在明显的负相关。在调整了包括对数转换后的25-羟维生素D水平和对数转换后的甲状旁腺激素水平等其他协变量后，这些关联仍然显著。
