Centro de Investigaciones Químicas, Universidad Autónoma del Estado de Morelos, Avenida Universidad No. 1001 Col. Chamilpa, 62209 Cuernavaca, Morelos, Mexico.
Molecules. 2012 Jan 17;17(1):861-72. doi: 10.3390/molecules17010861.
The plant Krameria pauciflora MOC et. Sessé ex DC. is used as an anti-inflammatory and antidiabetic in traditional medicine. The aim of this study was to evaluate the in vivo anti-inflammatory and antidiabetic effects of a methanol extract from the roots of K. pauciflora. Dichloromethane and ethyl acetate extracts obtained by partitioning the methanol extract were also evaluated. Complete methanol and dichloromethane extracts showed anti-inflammatory effects at 3 mg/kg. An anti-inflammatory effect similar to indomethacin (10 mg/kg) was observed when the methanol and dichloromethane extracts, which contain a cycloartane-type triterpene and an sterol, were administered orally at several doses (3, 10, 30 and 100 mg/kg), whereas no anti-inflammatory effect was observed at any dose for the ethyl acetate extract, which contains catechin-type flavonoids. The antidiabetic effect of each extract was also determined. An antihyperglycaemic effect was observed in diabetic rats, but no effect in normoglycaemic animals was observed when the methanol extract was administrated at 30 mg/kg. All of the extracts exhibited radical scavenger activity. Additionally, constituents from all of the extracts were identified by NMR. This article supports the use of K. pauciflora as an anti-inflammatory because it exhibits a similar effect to indomethacin. However, its antidiabetic effect is not completely clear, although it could be useful for preventing diabetic complications.
植物 Krameria pauciflora MOC et. Sessé ex DC. 在传统医学中被用作抗炎和抗糖尿病药物。本研究的目的是评估 K. pauciflora 根甲醇提取物的体内抗炎和抗糖尿病作用。还评估了通过甲醇提取物分配得到的二氯甲烷和乙酸乙酯提取物。完全甲醇和二氯甲烷提取物在 3mg/kg 时表现出抗炎作用。当以几个剂量（3、10、30 和 100mg/kg）口服给予含有环阿屯型三萜和甾醇的甲醇和二氯甲烷提取物时，观察到与吲哚美辛（10mg/kg）相似的抗炎作用，而含有儿茶素型类黄酮的乙酸乙酯提取物在任何剂量下均未显示抗炎作用。还确定了每种提取物的抗糖尿病作用。在糖尿病大鼠中观察到降血糖作用，但当以 30mg/kg 给予甲醇提取物时，在正常血糖动物中未观察到作用。所有提取物均表现出自由基清除活性。此外，通过 NMR 鉴定了所有提取物的成分。本文支持将 K. pauciflora 用作抗炎药，因为它具有与吲哚美辛相似的作用。然而，其抗糖尿病作用尚不清楚，尽管它可能有助于预防糖尿病并发症。
