Song Xuping, Liu Yu, Hu Yuling, Zhao Xiaoyan, Tian Jinhui, Ding Guowu, Wang Shigong
Key Laboratory for Semi-Arid Climate Change of the Ministry of Education, College of Atmospheric Sciences, Lanzhou University, Lanzhou 730000, China.
Center for Meteorological Environment and Human Health, Lanzhou University, Lanzhou 730000, China.
Int J Environ Res Public Health. 2016 Jun 28;13(7):642. doi: 10.3390/ijerph13070642.
The objective was to assess the transient association between air pollution and cardiac arrhythmia. Five databases were searched for studies investigating the association between daily increases in air pollutants (PM2.5, PM10, carbon monoxide, nitrogen dioxide, sulfur dioxide and ozone) and arrhythmia hospitalization or arrhythmia mortality. Two reviewers independently selected studies, extracted data, and assessed risk of bias. Outcomes were analyzed via a random-effects model and reported as relative risk and 95% confidence interval. 25 studies satisfied our inclusion criteria and 23 contributed to the meta-analysis. Arrhythmia hospitalization or mortality were associated with increases in PM2.5 (RR = 1.015 per 10 μg/m³, 95% CI: 1.006-1.024), PM10 (RR = 1.009 per 10 μg/m³, 95% CI: 1.004-1.014), carbon monoxide (RR = 1.041 per 1 ppm, 95% CI: 1.017-1.065), nitrogen dioxide (RR = 1.036 per 10 ppb, 95% CI: 1.020-1.053), and sulfur dioxide (RR = 1.021 per 10 ppb, 95% CI: 1.003-1.039), but not ozone (RR = 1.012 per 10 ppb, 95% CI: 0.997-1.027). Both particulate and gaseous components, with the exception of ozone, have a temporal association with arrhythmia hospitalization or mortality. Compared with Europe and North America, a stronger association was noted in Asia.
目的是评估空气污染与心律失常之间的短暂关联。检索了五个数据库，以查找研究每日空气污染物（细颗粒物2.5、可吸入颗粒物10、一氧化碳、二氧化氮、二氧化硫和臭氧）增加与心律失常住院或心律失常死亡率之间关联的研究。两名评审员独立选择研究、提取数据并评估偏倚风险。通过随机效应模型分析结果，并报告为相对风险和95%置信区间。25项研究符合我们的纳入标准，23项纳入荟萃分析。心律失常住院或死亡率与细颗粒物2.5（每10μg/m³相对风险=1.015，95%置信区间：1.006-1.024）、可吸入颗粒物10（每10μg/m³相对风险=1.009，95%置信区间：1.004-1.014）、一氧化碳（每1ppm相对风险=1.041，95%置信区间：1.017-1.065）、二氧化氮（每10ppb相对风险=1.036，95%置信区间：1.020-1.053）和二氧化硫（每10ppb相对风险=1.021，95%置信区间：1.003-1.039）的增加相关，但与臭氧无关（每10ppb相对风险=1.012，95%置信区间：0.997-1.027）。除臭氧外，颗粒物和气态成分均与心律失常住院或死亡率存在时间关联。与欧洲和北美相比，亚洲的关联更强。
