Kissig Megan, Shapira Suzanne N, Seale Patrick
Department of Cell & Developmental Biology and Institute for Diabetes, Obesity, and Metabolism, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA.
Cell. 2016 Jun 30;166(1):258-258.e1. doi: 10.1016/j.cell.2016.06.038.
Brown and beige adipose tissues have been identified as potential therapeutic targets for combating diet-induced obesity and metabolic disease. Here, we present transcriptional and developmental regulation of brown and beige adipose tissue, as well as critical physiological and pharmaceutical activators of thermogenesis in both tissues.
棕色脂肪组织和米色脂肪组织已被确定为对抗饮食诱导的肥胖和代谢疾病的潜在治疗靶点。在此,我们阐述了棕色和米色脂肪组织的转录和发育调控,以及这两种组织中产热的关键生理和药物激活剂。