Zhang J, Yan H G, Chi Y, Guo C Y, Yang L
Department of Ophthalmology, Peking University First Hospital, Key Laboratory of Vision Loss and Restoration, Ministry of Education, Beijing 100034, China.
Zhonghua Yan Ke Za Zhi. 2016 Jun 11;52(6):429-36. doi: 10.3760/cma.j.issn.0412-4081.2016.06.007.
To evaluate vision-and health-related quality of life in patients with uveitis, and to evaluate the relationship between quality of life and visual acuity.
Cross-sectional study. One hundred and eleven patients with uveitis were enrolled in the study from January 1, 2013 to April 1, 2014 in Peking University First Hospital. Clinical data collected included medical history, complete ophthalmologic examination and best corrected visual acuity (LogMAR). Basic clinical data (gender, diagnosis, etc.) was also collected. The National Eye Institute Visual Functioning Questionnaire (NEI VFQ-25) and the 36-Item Short Form Health Survey (SF-36) were administered. The patients were divided into two groups, anterior uveitis group (ATU), and other types of uveitis in this study (OTU). T-test was used for analysis of the data which obey standard normal distribution, otherwise rank sum test was used for data analysis. Correlation and Linear regression were constructed between bilateral visual acuity and the scores of NEI VFQ-25 and SF-36 questionnaires.
For all the 111 cases included in this study, 87 (78.4%) of them were anterior uveitis (ATU), 5 of them were intermediate uveitis, 7 of them were posterior uveitis and 12 of them were pan uveitis. Mean visual acuity of better and worse eye were 0.0 and 0.2 in ATU patients, respectively. Mean visual acuity of better and worse eye were 0.1 and 0.4 in OTU patients, respectively. Patients rated the general health subscale score of NEI VFQ-25 and SF-36 lower than other subscales, respectively (score of general health was 25.0 (25.0-50.0) in NEI VFQ-25 and 46.8 (19.8) in SF-36). ATU group scored higher that OTU group (Mean score of SF-36 was 77.5 (10.7) and 68.8 (16.9) in ATU and OTU group respectively, P value of SF-36< 0.01, t=9.54. Mean score of NEI VFQ-25 was 77.3 (12.8) and 59.1 (16.5) in ATU and OTU group respectively, P value of NEI VFQ-25<0.01, t=33.16). Mean score of NEI VFQ-25 of all patients was 73.4 (15.5). Mean visual acuity of better eye and worse eye of all patients were 0.0 (-0.2-1.0) and 0.3 (0.5), respectively. The correlation coefficient was -0.497 (P<0.01, t=-5.98) between NEI VFQ -25 score and visual acuity in better eye, and -0.32 (t=-3.48, P<0.01) between NEI VFQ-25 score and visual acuity in worse eye. The coefficient was -3.9 in linear regression of visual acuity in better eye against NEI VFQ-25 score (t=-5.98, P<0.01), and -1.1 of visual acuity in worse eye against NEI VFQ-25 score (t=-3.48,P<0.01).
General health was more affected than other function subscales in uveitis. The quality of life in anterior uveitis was higher than other types of uveitis in this study. Vision-related quality of life correlated with both eyes.(Chin J Ophthalmol, 2016, 52: 429-436).
评估葡萄膜炎患者的视力及与健康相关的生活质量，并评估生活质量与视力之间的关系。
横断面研究。2013年1月1日至2014年4月1日期间，北京大学第一医院招募了111例葡萄膜炎患者。收集的临床资料包括病史、完整的眼科检查及最佳矫正视力（LogMAR）。还收集了基本临床资料（性别、诊断等）。采用美国国立眼科研究所视觉功能问卷（NEI VFQ-25）和36项简明健康调查问卷（SF-36）进行评估。本研究将患者分为两组，前葡萄膜炎组（ATU）和其他类型葡萄膜炎组（OTU）。对于服从标准正态分布的数据，采用t检验进行分析，否则采用秩和检验进行数据分析。构建双眼视力与NEI VFQ-25及SF-36问卷得分之间的相关性和线性回归分析。
本研究纳入的111例患者中，87例（78.4%）为前葡萄膜炎（ATU），5例为中间葡萄膜炎，7例为后葡萄膜炎，12例为全葡萄膜炎。ATU组患者较好眼和较差眼的平均视力分别为0.0和0.2。OTU组患者较好眼和较差眼的平均视力分别为0.1和0.4。患者对NEI VFQ-25和SF-36的总体健康子量表评分分别低于其他子量表（NEI VFQ-25中总体健康评分为25.0（25.0 - 50.0），SF-36中为46.8（19.8））。ATU组得分高于OTU组（ATU组和OTU组SF-36的平均得分分别为77.5（10.7）和68.8（16.9），SF-36的P值<0.01，t = 9.54。ATU组和OTU组NEI VFQ-25的平均得分分别为77.3（12.8）和59.1（16.5），NEI VFQ-25的P值<0.01，t = 33.16）。所有患者NEI VFQ-25的平均得分为73.4（15.5）。所有患者较好眼和较差眼的平均视力分别为0.0（-0.2 - 1.0）和0.3（0.5）。NEI VFQ -25得分与较好眼视力之间的相关系数为-0.497（P<0.01，t = -5.98），与较差眼视力之间的相关系数为-0.32（t = -3.48，P<0.01）。较好眼视力相对于NEI VFQ-25得分的线性回归系数为-3.9（t = -5.98，P<0.01），较差眼视力相对于NEI VFQ-25得分的线性回归系数为-1.1（t = -3.48，P<0.01）。
葡萄膜炎患者的总体健康较其他功能子量表受影响更大。本研究中，前葡萄膜炎患者的生活质量高于其他类型的葡萄膜炎。与视力相关的生活质量与双眼均相关。（《中华眼科杂志》，2016年，52: 429 - 436）
