Sassolini Alessandro, Brinchi Giampaolo, Di Gennaro Antonio, Dionisi Simone, Dominici Carola, Fantozzi Luca, Onofri Giorgio, Piazza Rosario, Guidotti Maurizio
Regional Agency for Environmental Protection, Via Salaria per L'Aquila 6-8, 02100, Rieti, Italy.
Bull Environ Contam Toxicol. 2016 Sep;97(3):432-8. doi: 10.1007/s00128-016-1860-1. Epub 2016 Jul 6.
The chemicals warfare agents (CWAs) are an extremely toxic class of molecules widely produced in many industrialized countries for decades, these compounds frequently contained arsenic. The plants where the CWAs have been produced or the plants where they have been demilitarized after the Second World War with unacceptable techniques can represent a serious environmental problem. CWAs standards are difficult to find on market so in present work an environmental assessment method based on markers has been proposed. Triphenylarsine, phenylarsine oxide and thiodiglycol have been selected as markers. Three reliable analytical methods based on gaschromatography and mass detection have been proposed and tested for quantitative analysis of markers. Methods performance have been evaluated testing uncertainty, linearity, recovery and detection limits and also comparing detection limits with exposure limits of reference CWAs. Proposed assessment methods have been applied to a case study of a former industrial plant sited in an area characterized by a high background of mineral arsenic.
化学战剂（CWAs）是一类毒性极强的分子，几十年来在许多工业化国家广泛生产，这些化合物常含有砷。生产化学战剂的工厂，或二战后采用不可接受的技术进行非军事化处理的工厂，可能会造成严重的环境问题。市场上很难找到化学战剂标准，因此在当前工作中，提出了一种基于标志物的环境评估方法。三苯基砷、苯基氧化砷和硫二甘醇已被选为标志物。提出并测试了三种基于气相色谱和质谱检测的可靠分析方法，用于标志物的定量分析。通过测试不确定度、线性、回收率和检测限，并将检测限与参考化学战剂的暴露限值进行比较，对方法性能进行了评估。所提出的评估方法已应用于一个位于矿物砷背景较高地区的 former industrial plant 的案例研究。 （注：“former industrial plant”原文表述有误，推测可能是“former industrial site”之类，暂按原文翻译）
