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芹菜提取物对佐剂诱导性关节炎大鼠肝脏氧化应激的影响。

Effects of Apium graveolens Extract on the Oxidative Stress in the Liver of Adjuvant-Induced Arthritic Rats.

作者信息

Sukketsiri Wanida, Chonpathompikunlert Pennapa, Tanasawet Supita, Choosri Nutjanat, Wongtawatchai Tulaporn

机构信息

Department of Pharmacology, Faculty of Science, Prince of Songkla University, Songkhla 90112, Thailand.

Department of Physiology, Faculty of Science, Prince of Songkla University, Songkhla 90112, Thailand.

出版信息

Prev Nutr Food Sci. 2016 Jun;21(2):79-84. doi: 10.3746/pnf.2016.21.2.79. Epub 2016 Jun 30.

DOI:10.3746/pnf.2016.21.2.79
PMID:27390722
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4935245/
Abstract

Apium graveolens Linn. (Apiaceae) is an indigenous plant of the North and South Americas, Southern Europe, and Asia and has been widely used as a food or a traditional medicine for treatment of inflammation and arthritis. The purpose of this study was to investigate the antioxidant effects of a methanolic extract of A. graveolens (AGE) against liver oxidative stress in an adjuvant-induced arthritic rat model. The AGE (250, 500, and 1,000 mg/kg) was given orally for 24 consecutive days after induction by injecting complete Freund's adjuvant. Liver and spleen weights were recorded. The superoxide anion level, total peroxide (TP), glutathione peroxidase (GPx) activity, superoxide dismutase (SOD) activity, total antioxidant status, and oxidative stress index (OSI) were also measured. AGE treatment significantly decreased the levels of the superoxide anion, TP, and OSI whereas the GPx and SOD activities significantly increased in the liver of the arthritic rats. These results indicated that AGE showed an ameliorative effect against liver oxidative stress in adjuvant-induced arthritic rats by reducing the generation of liver free radicals and increasing the liver antioxidant enzyme activity.

摘要

芹菜（伞形科）是一种原产于南北美洲、南欧和亚洲的植物，已被广泛用作食物或传统药物，用于治疗炎症和关节炎。本研究的目的是在佐剂诱导的关节炎大鼠模型中，研究芹菜甲醇提取物（AGE）对肝脏氧化应激的抗氧化作用。在注射完全弗氏佐剂诱导后，连续24天口服给予AGE（250、500和1000mg/kg）。记录肝脏和脾脏重量。还测量了超氧阴离子水平、总过氧化物（TP）、谷胱甘肽过氧化物酶（GPx）活性、超氧化物歧化酶（SOD）活性、总抗氧化状态和氧化应激指数（OSI）。AGE处理显著降低了关节炎大鼠肝脏中超氧阴离子、TP和OSI的水平，而GPx和SOD活性显著增加。这些结果表明，AGE通过减少肝脏自由基的产生和增加肝脏抗氧化酶活性，对佐剂诱导的关节炎大鼠的肝脏氧化应激具有改善作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9c09/4935245/26a8529a1a8a/pnfs-21-79f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9c09/4935245/ebc7b9e81f2b/pnfs-21-79f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9c09/4935245/608530debcb0/pnfs-21-79f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9c09/4935245/80c4d9550129/pnfs-21-79f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9c09/4935245/ffffa5027299/pnfs-21-79f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9c09/4935245/26a8529a1a8a/pnfs-21-79f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9c09/4935245/ebc7b9e81f2b/pnfs-21-79f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9c09/4935245/608530debcb0/pnfs-21-79f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9c09/4935245/80c4d9550129/pnfs-21-79f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9c09/4935245/ffffa5027299/pnfs-21-79f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9c09/4935245/26a8529a1a8a/pnfs-21-79f5.jpg

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