Yeo Ingwon, Cha Hoon-Suk, Yoon Young Cheol, Park Youn-Soo, Lim Seung-Jae
Department of Orthopedic Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine Department of Radiology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea.
Medicine (Baltimore). 2016 Jul;95(27):e4168. doi: 10.1097/MD.0000000000004168.
Synovitis, acne, pustulosis, hyperostosis, and osteitis (SAPHO) syndrome is an increasingly recognized entity. The hip joint is known as a less frequently affected site in SAPHO syndrome, and there has been limited reports about hip joint diseases caused by SAPHO syndrome, and as such adequate treatment for this disease spectrum is still not fully elucidated.
We describe the case of a 52-year-old man admitted for SAPHO syndrome who went on to be diagnosed with advanced secondary hip arthritis associated with disabling right hip pain. The diagnosis of SAPHO syndrome was delayed; the patient was given a clinical diagnosis of osteomyelitis and treated with prolonged courses of antibiotics and open surgical debridement at previous tertiary health facility. The patient underwent 2-stage joint replacement surgery in our hospital. At 1 year after the surgery, he is well, with minimal right hip pain and the prosthesis is functioning well.
This case shows the safety and effectiveness of the 2-stage joint replacement in treating destructive hip disease caused by SAPHO syndrome mimicking infectious arthritis.
滑膜炎、痤疮、脓疱病、骨肥厚和骨炎（SAPHO）综合征是一种越来越被认可的病症。髋关节是SAPHO综合征中较少受累的部位，关于由SAPHO综合征引起的髋关节疾病的报道有限，因此针对这一疾病谱的充分治疗仍未完全阐明。
我们描述了一名因SAPHO综合征入院的52岁男性病例，该患者后来被诊断为与右髋关节疼痛致残相关的晚期继发性髋关节炎。SAPHO综合征的诊断被延迟；该患者在之前的三级医疗机构被临床诊断为骨髓炎，并接受了长期的抗生素治疗和开放性手术清创。该患者在我院接受了两阶段关节置换手术。术后1年，他情况良好，右髋关节疼痛轻微，假体功能良好。
本病例显示了两阶段关节置换治疗由SAPHO综合征模拟感染性关节炎引起的破坏性髋关节疾病的安全性和有效性。
