Hsieh You-Liang, Shibu Marthandam Asokan, Lii Chong-Kuei, Viswanadha Vijaya Padma, Lin Yi-Lin, Lai Chao-Hung, Chen Yu-Feng, Lin Kuan-Ho, Kuo Wei-Wen, Huang Chih-Yang
Department of Health and Nutrition Biotechnology, Asia University, Taichung, Taiwan.
Graduate Institute of Basic Medical Science, China Medical University, Taichung, Taiwan.
J Ethnopharmacol. 2016 Nov 4;192:170-177. doi: 10.1016/j.jep.2016.07.018. Epub 2016 Jul 9.
Andrographis paniculata (Burm. f.) Nees (Acanthaceae) has a considerable medicinal reputation in most parts of Asia as a potent medicine in the treatment of Endocrine disorders, inflammation and hypertension.
Water extract of A. paniculata and its active constituent andrographolide are known to possess anti-inflammatory and anti-apoptotic effects. Our aim is to identify whether A. paniculata extract could protect myocardial damage in high-fat diet induced obese mice.
The test mice were divided into three groups fed either with normal chow or with high fat diet (obese) or with high fat diet treated with A. paniculata extract (2g/kg/day, through gavage, for a week).
We found that the myocardial inflammation pathway related proteins were increased in the obese mouse which potentially contributes to cardiac hypertrophy and myocardial apoptosis. But feeding with A. paniculata extract showed significant inhibition on the effects of high fat diet.
Our study strongly suggests that supplementation of A. paniculata extract can be used for prevention and treatment of cardiovascular disease in obese patients.
穿心莲（爵床科）在亚洲大部分地区作为治疗内分泌失调、炎症和高血压的有效药物享有很高的药用声誉。
已知穿心莲水提取物及其活性成分穿心莲内酯具有抗炎和抗凋亡作用。我们的目的是确定穿心莲提取物是否能保护高脂饮食诱导的肥胖小鼠的心肌损伤。
将实验小鼠分为三组，分别喂食正常饲料、高脂饮食（肥胖）或高脂饮食并经穿心莲提取物处理（2克/千克/天，通过灌胃，持续一周）。
我们发现肥胖小鼠中心肌炎症途径相关蛋白增加，这可能导致心脏肥大和心肌细胞凋亡。但喂食穿心莲提取物对高脂饮食的影响有显著抑制作用。
我们的研究强烈表明，补充穿心莲提取物可用于肥胖患者心血管疾病的预防和治疗。
