人参皂苷Re在正常生长条件下可改善HaCaT角质形成细胞的皮肤屏障功能。
Ginsenoside Re improves skin barrier function in HaCaT keratinocytes under normal growth conditions.
作者信息
Oh Yuri, Lim Hye-Won, Kim Kyunghoon, Lim Chang-Jin
机构信息
a Department of Biological Sciences , Kangwon National University , Chuncheon , Korea.
b Shebah Biotech Inc. , Chuncheon , Korea.
出版信息
Biosci Biotechnol Biochem. 2016 Nov;80(11):2165-2167. doi: 10.1080/09168451.2016.1206808. Epub 2016 Jul 13.
Ginsenoside Re (Re), a major ginsenoside of ginseng, enhanced the cornified cell envelope (CE) formation in HaCaT keratinocytes under normal conditions. In HaCaT keratinocytes, Re was also able to upregulate filaggrin protein and caspase-14 activity in a concentration-dependent manner. These findings reasonably imply that Re possesses a desirable property of improving skin barrier function.
人参皂苷Re（Re）是人参的主要人参皂苷，在正常条件下可增强HaCaT角质形成细胞中角质化细胞包膜（CE）的形成。在HaCaT角质形成细胞中，Re还能够以浓度依赖性方式上调丝聚合蛋白和半胱天冬酶-14的活性。这些发现合理地表明，Re具有改善皮肤屏障功能的理想特性。
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