采用组织培养技术通过估计活病毒含量对口服脊髓灰质炎疫苗进行效价滴定。
Potency Titration of Oral Polio Vaccine by Estimation of Live Virus Content Using Tissue Culture Technique.
作者信息
Eswaran Shiva Priya, Praharaj A K, Chander Y, Nagendra A
机构信息
Ex-Post Graduate Student (Microbiology), Armed Forces Medical College, Pune - 411 040.
Senior Advisor (Pathology and Microbiology), 151 Base Hospital, C/o 99 APO.
出版信息
Med J Armed Forces India. 2003 Apr;59(2):105-7. doi: 10.1016/S0377-1237(03)80049-7. Epub 2011 Jul 21.
Representative vaccines from 34 different batches of oral log10 (6.425) and a minimum titre of polio vaccine (OPV) were tested for potency by tissue culture technique. All 34 samples were found to be potent, a maximum titre of log10 (6.425) and a minimum titre of log10 (5.86) was obtained. In addition, 6 vaccines from the immunisation clinic (left over sample after immunisation) were also subjected to potency titration and their potency was found to be within normal limits. Adequate potency confirmed ideal storage condition of the vaccines in Armed Forces set up.
采用组织培养技术对来自34个不同批次、口服对数10（6.425）且脊髓灰质炎疫苗（OPV）最低效价的代表性疫苗进行了效力测试。发现所有34个样本均有效，获得的最高效价为对数10（6.425），最低效价为对数10（5.86）。此外，还对免疫诊所的6种疫苗（免疫后剩余样本）进行了效力滴定，发现其效力在正常范围内。充足的效力证实了武装部队机构中疫苗的理想储存条件。
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