Wang Jing, Zhao Lei, Yan Han, Che Juanjuan, Huihui Li, Jun Wu, Liu Bing, Cao Bangwei
Department of Oncology, Beijing Friendship Hospital, Capital Medical University, Beijing, China.
Department of Emergency, Beijing Friendship Hospital, Capital Medical University, Beijing, China.
PLoS One. 2016 Jul 13;11(7):e0159140. doi: 10.1371/journal.pone.0159140. eCollection 2016.
Esophageal cancer is a common and aggressive malignant tumor. This study aimed to investigate the association between human papillomavirus (HPV) Types 16 and 18 and esophageal carcinoma (EC) in the world population by conducting a meta-analysis.
Computerized bibliographic and manual searches were performed to identify all eligible literatures between 1982 and 2014. PUBMED (http://www.ncbi.nlm.nih.gov/pubmed/) and CNKI (http://www.cnki.net/) were the primary sources of case-control studies, and key words used include human papillomavirus, HPV, esophageal, esophagus, cancer, carcinoma, and tumor. All searches were performed by reviewing articles and abstracts cited in the published systematic reviews and case-control studies. Prospective studies that reported relative risk (RR) estimates with 95% CIs for the association between HPV and EC were included.
Thirty-three randomized studies were identified, and the main features of these trials were included in this systematic review. HPV infection rate in the EC group was 46.5%, while HPV infection rate in the control group was 26.2% (OR = 1.62; 95% CI, 1.33-1.98). In China, the merger OR value was 1.62 (95% CI: 1.26-2.07); while in the Asian region, the merger OR value was 1.63 (95% CI: 1.29-2.04). There were statistical differences in HPV testing due to different detection methods such as PCR, IHC and ISH. In the PCR detection group, the merger OR value was 1.61 (95% CI: 1.33-1.95).
These results indicate that HPV infection and the incidence of EC are closely associated.
食管癌是一种常见的侵袭性恶性肿瘤。本研究旨在通过荟萃分析探讨16型和18型人乳头瘤病毒（HPV）与世界人群食管癌（EC）之间的关联。
通过计算机文献检索和人工检索，识别1982年至2014年间所有符合条件的文献。PUBMED（http://www.ncbi.nlm.nih.gov/pubmed/）和中国知网（http://www.cnki.net/）是病例对照研究的主要来源，使用的关键词包括人乳头瘤病毒、HPV、食管、食道癌、癌症、癌和肿瘤。所有检索均通过查阅已发表的系统评价和病例对照研究中引用的文章和摘要进行。纳入报告HPV与EC之间关联的相对风险（RR）估计值及95%可信区间（CI）的前瞻性研究。
共识别出33项随机研究，这些试验的主要特征纳入本系统评价。EC组HPV感染率为46.5%，而对照组HPV感染率为26.2%（比值比[OR]=1.62；95%CI，1.33 - 1.98）。在中国，合并OR值为1.62（95%CI：1.26 - 2.07）；而在亚洲地区，合并OR值为1.63（95%CI：1.29 - 2.04）。由于PCR、免疫组化（IHC）和原位杂交（ISH）等不同检测方法，HPV检测存在统计学差异。在PCR检测组，合并OR值为1.61（95%CI：1.33 - 1.95）。
这些结果表明HPV感染与EC的发生率密切相关。
