Mohammadpour Bashir, Rouhi Samaneh, Khodabandehloo Mazaher, Moradi Masoud
Student Research Committee, Kurdistan University of Medical Sciences, Sanandaj, Iran.
Cellular & Molecular Research Center, Kurdistan University of Medical Sciences, Sanandaj, Iran.
Iran J Public Health. 2019 Jul;48(7):1215-1226.
Human papillomavirus (HPV) can infect the epithelium of the esophagus, but so far there is no reliable and comprehensive evidence about the prevalence and association of HPV with esophageal cancer in Iran, as high incidence region. This study aimed to evaluate the prevalence and association of HPV with esophageal squamous cell carcinoma (ESCC) in Iran.
Relevant English and Persian articles published up to Aug 2017 and indexed in databases were reviewed. Frequency of HPV genotypes in ESCC cases and controls was surveyed according to regions of Iran. Data were meta-analyzed with random effects models using Comprehensive Meta-Analysis software.
Overall, 14 studies were eligible including 1444 samples (1062 ESCC cases and 382 controls). HPV was positive in 269 (25.32%) of 1062 ESCC cases and in 65 (17.01%) of 382 controls. Total prevalence of HPV in both groups was estimated 0.256 (95%CI, 0.208%-0.310%). The prevalence of HPV-16 and HPV-18 was estimated 0.121 (95%CI: 0.087-0.183) and 0.046 (95%CI; 0.023-0.088), respectively. The difference in HPV prevalence in different regions of Iran was statistically significant (Q=18.20, df =4, =0.001). In 6 case-control studies, the pooled odds ratio was estimated 1.99 (95%CI; 0.916-4.315).
High-risk HPVs were observed in ESCC cases and controls from different regions of Iran. The odds ratio indicates that the HPV infection in ESCC cases was approximately 2 fold more than the controls. More case-control studies in other populations with larger sample size are necessary.
人乳头瘤病毒（HPV）可感染食管上皮，但迄今为止，在伊朗这个食管癌高发地区，尚无关于HPV在食管癌中的流行情况及其与食管癌关联的可靠且全面的证据。本研究旨在评估伊朗HPV在食管鳞状细胞癌（ESCC）中的流行情况及其与ESCC的关联。
回顾了截至2017年8月发表并被数据库收录的相关英文和波斯文文章。根据伊朗不同地区调查ESCC病例和对照中HPV基因型的频率。使用综合Meta分析软件，采用随机效应模型对数据进行Meta分析。
总体而言，14项研究符合要求，共纳入1444个样本（1062例ESCC病例和382例对照）。1062例ESCC病例中有269例（25.32%）HPV呈阳性，382例对照中有65例（17.01%）HPV呈阳性。两组中HPV的总流行率估计为0.256（95%CI，0.208%-0.310%）。HPV-16和HPV-18的流行率估计分别为0.121（95%CI：0.087-0.183）和0.046（95%CI；0.023-0.088）。伊朗不同地区HPV流行率的差异具有统计学意义（Q=18.20，df =4，P=0.001）。在6项病例对照研究中，合并比值比估计为1.99（95%CI；0.9(916)-4.315）。
在伊朗不同地区的ESCC病例和对照中均观察到高危型HPV。比值比表明ESCC病例中的HPV感染率约为对照的2倍。有必要在其他人群中开展更多样本量更大的病例对照研究。
