Tomiyasu Taneto, Nozaki Miho, Yoshida Munenori, Ogura Yuichiro
Invest Ophthalmol Vis Sci. 2016 Jul 1;57(9):OCT324-30. doi: 10.1167/iovs.15-18898.
The purpose of this study was to compare the angiographic findings of polypoidal choroidal vasculopathy (PCV) detected by indocyanine green angiography (ICGA) and en face optical coherence tomography angiography (OCTA).
The study design was a retrospective chart review of 20 eyes with a clinical diagnosis of treatment-naive PCV, seen at Nagoya City University Hospital between December 2014 and January 2016. Indocyanine green angiography was performed with Heidelberg Retina Angiography 2 and OCTA was performed by using Avanti RTVue XR.
Twenty eyes of 20 patients (18 male, 2 female) were studied. Average age was 71.9 years. Manual segmentation was required to detect the pathologic lesions of PCV in all cases. The polypoidal lesions were detected in 20 eyes (100%) by ICGA, and in 17 eyes (85%) by OCTA. The number of polypoidal lesions detected by OCTA averaged 2.6 ± 1.9, with an average of 2.0 ± 1.1 by ICGA (P < 0.05). The branching vascular network (BVN) was detected in 14 eyes (70%) by ICGA and in 14 eyes (70%) by OCTA. All of the BVNs detected by OCTA were located between the RPE and Bruch's membrane.
Despite the manual segmentation required, en face OCTA enabled us to analyze the angiographic features of PCV combined with longitudinal image (B-scan). En face OCTA may be useful for understanding the pathogenesis of PCV and managing PCV.
本研究旨在比较经吲哚青绿血管造影（ICGA）和正面光学相干断层扫描血管造影（OCTA）检测的息肉样脉络膜血管病变（PCV）的血管造影结果。
本研究设计为一项回顾性图表审查，纳入了2014年12月至2016年1月在名古屋市立大学医院就诊的20只初诊为PCV的眼睛。使用海德堡视网膜血管造影2进行吲哚青绿血管造影，使用Avanti RTVue XR进行OCTA检查。
研究了20例患者的20只眼睛（男性18例，女性2例）。平均年龄为71.9岁。所有病例均需要手动分割以检测PCV的病理病变。ICGA在20只眼中（100%）检测到息肉样病变，OCTA在17只眼中（85%）检测到。OCTA检测到的息肉样病变数量平均为2.6±1.9，ICGA平均为2.0±1.1（P<0.05）。ICGA在14只眼中（70%）检测到分支血管网（BVN），OCTA在14只眼中（70%）检测到。OCTA检测到的所有BVN均位于视网膜色素上皮（RPE）和 Bruch膜之间。
尽管需要手动分割，但正面OCTA使我们能够结合纵向图像（B扫描）分析PCV的血管造影特征。正面OCTA可能有助于理解PCV的发病机制并管理PCV。
