Radziejewska Iwona
Department of Medical Chemistry, Medical University of Białystok, ul. Mickiewicza 2a, 15-222 Białystok, Poland.
Cancers (Basel). 2023 May 9;15(10):2680. doi: 10.3390/cancers15102680.
Aberrant glycosylation of cell surface proteins is a very common feature of many cancers. One of the glycoproteins, which undergoes specific alterations in the glycosylation of tumor cells is epithelial MUC1 mucin, which is highly overexpressed in the malignant state. Such changes lead to the appearance of tumor associated carbohydrate antigens (TACAs) on MUC1, which are rarely seen in healthy cells. One of these structures is the Thomsen-Friedenreich disaccharide Galβ1-3GalNAc (T or TF antigen), which is typical for about 90% of cancers. It was revealed that increased expression of the T antigen has a big impact on promoting cancer progression and metastasis, among others, due to the interaction of this antigen with the β-galactose binding protein galectin-3 (Gal-3). In this review, we summarize current information about the interactions between the T antigen on MUC1 mucin and Gal-3, and their impact on cancer progression and metastasis.
细胞表面蛋白的异常糖基化是许多癌症的一个非常常见的特征。其中一种糖蛋白，即上皮性MUC1粘蛋白，在肿瘤细胞的糖基化过程中会发生特异性改变，在恶性状态下高度过表达。这种变化导致MUC1上出现肿瘤相关碳水化合物抗原（TACAs），而这些抗原在健康细胞中很少见。其中一种结构是Thomsen-Friedenreich二糖Galβ1-3GalNAc（T或TF抗原），约90%的癌症都有这种典型特征。研究表明，T抗原表达的增加对促进癌症进展和转移有很大影响，尤其是由于该抗原与β-半乳糖结合蛋白半乳糖凝集素-3（Gal-3）的相互作用。在这篇综述中，我们总结了目前关于MUC1粘蛋白上的T抗原与Gal-3之间相互作用的信息，以及它们对癌症进展和转移的影响。
