Lawman Samuel, Dong Yue, Williams Bryan M, Romano Vito, Kaye Stephen, Harding Simon P, Willoughby Colin, Shen Yao-Chun, Zheng Yalin
Opt Express. 2016 May 30;24(11):12395-405. doi: 10.1364/OE.24.012395.
We report the development of a Spectral Domain Line Field Optical Coherence Tomography (LF-OCT) system, using a broad bandwidth and spatial coherent Super-Continuum (SC) source. With conventional quasi-Continuous Wave (CW) setup we achieve axial resolutions up to 2.1 μm in air and 3D volume imaging speeds up to 213 kA-Scan/s. Furthermore, we report the use of a single SC pulse, of 2 ns duration, to temporally gate an OCT B-Scan image of 70 A-Scans. This is the equivalent of 35 GA-Scans/s. We apply the CW setup for high resolution imaging of the fine structures of a human cornea sample ex-vivo. The single pulse setup is applied to imaging of a coated pharmaceutical tablet. The fixed pattern noise due to spectral noise is removed by subtracting the median magnitude A-Scan. We also demonstrate that the Fourier phase can be used to remove aberration caused artefacts.
我们报告了一种光谱域线场光学相干断层扫描(LF - OCT)系统的开发情况,该系统使用了宽带宽和空间相干的超连续谱(SC)光源。在传统的准连续波(CW)设置下,我们在空气中实现了高达2.1μm的轴向分辨率以及高达213 kA - 扫描/秒的三维体积成像速度。此外,我们报告了使用持续时间为2 ns的单个SC脉冲对包含70次A - 扫描的OCT B - 扫描图像进行时间选通。这相当于35 GA - 扫描/秒。我们将CW设置应用于离体人类角膜样本精细结构的高分辨率成像。单个脉冲设置应用于包衣药物片剂的成像。通过减去中值幅度A - 扫描来消除由光谱噪声引起的固定模式噪声。我们还证明了傅里叶相位可用于消除像差引起的伪像。