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利用线场光谱域光学相干断层扫描技术进行高分辨率角膜和单脉冲成像。

High resolution corneal and single pulse imaging with line field spectral domain optical coherence tomography.

作者信息

Lawman Samuel, Dong Yue, Williams Bryan M, Romano Vito, Kaye Stephen, Harding Simon P, Willoughby Colin, Shen Yao-Chun, Zheng Yalin

出版信息

Opt Express. 2016 May 30;24(11):12395-405. doi: 10.1364/OE.24.012395.

Abstract

We report the development of a Spectral Domain Line Field Optical Coherence Tomography (LF-OCT) system, using a broad bandwidth and spatial coherent Super-Continuum (SC) source. With conventional quasi-Continuous Wave (CW) setup we achieve axial resolutions up to 2.1 μm in air and 3D volume imaging speeds up to 213 kA-Scan/s. Furthermore, we report the use of a single SC pulse, of 2 ns duration, to temporally gate an OCT B-Scan image of 70 A-Scans. This is the equivalent of 35 GA-Scans/s. We apply the CW setup for high resolution imaging of the fine structures of a human cornea sample ex-vivo. The single pulse setup is applied to imaging of a coated pharmaceutical tablet. The fixed pattern noise due to spectral noise is removed by subtracting the median magnitude A-Scan. We also demonstrate that the Fourier phase can be used to remove aberration caused artefacts.

摘要

我们报告了一种光谱域线场光学相干断层扫描(LF - OCT)系统的开发情况,该系统使用了宽带宽和空间相干的超连续谱(SC)光源。在传统的准连续波(CW)设置下,我们在空气中实现了高达2.1μm的轴向分辨率以及高达213 kA - 扫描/秒的三维体积成像速度。此外,我们报告了使用持续时间为2 ns的单个SC脉冲对包含70次A - 扫描的OCT B - 扫描图像进行时间选通。这相当于35 GA - 扫描/秒。我们将CW设置应用于离体人类角膜样本精细结构的高分辨率成像。单个脉冲设置应用于包衣药物片剂的成像。通过减去中值幅度A - 扫描来消除由光谱噪声引起的固定模式噪声。我们还证明了傅里叶相位可用于消除像差引起的伪像。

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