Chen Chaoliang, Shi Weisong, Reyes Robnier, Yang Victor X D
Biophotonics and Bioengineering Lab, Department of Electrical, Computer, and Biomedical Engineering, Ryerson University, Toronto, Ontario, Canada.
Department of Optical Engineering, Nanjing University of Science and Technology, Nanjing, Jiangsu, China.
Biomed Opt Express. 2018 Nov 28;9(12):6529-6544. doi: 10.1364/BOE.9.006529. eCollection 2018 Dec 1.
In super-continuum (SC) source based spectral domain optical coherence tomography (SC-SDOCT), the stability of the power spectral density (PSD) has a significant impact on OCT system sensitivity and image signal to noise ratio (SNR). High speed imaging decreases the camera's exposure time, thus each A-scan contained fewer laser pulse excited SC wideband emissions, resulting in a decrease of SNR. In this manuscript, we present a buffer-averaging SC-SDOCT (BASC-SDOCT) to improve the system's performance without losing imaging speed, taking advantage of the excess output power from typical SC sources. In our proposed technique, the output light from SC was passed through a fiber based light buffering and averaging system to improve the PSD stability by averaging 8 SC emissions. The results showed that 6.96 µs of SC emission after buffering and averaging can achieve the same PSD stability equivalent to a longer exposure time of 55.68 µs, despite increasing the imaging speed from 16.8 kHz to 91.9 kHz. The system sensitivity was improved by 8.6 dB, reaching 100.6 dB, which in turn improved SNR of structural imaging, Doppler OCT velocity measurement, and speckle variance OCT (SVOCT) angiographic imaging as demonstrated by phantom and experiments.
在基于超连续谱(SC)光源的光谱域光学相干断层扫描(SC-SDOCT)中,功率谱密度(PSD)的稳定性对光学相干断层扫描(OCT)系统的灵敏度和图像信噪比(SNR)有重大影响。高速成像会缩短相机的曝光时间,因此每个A扫描包含的激光脉冲激发的SC宽带发射较少,导致信噪比降低。在本论文中,我们提出了一种缓冲平均SC-SDOCT(BASC-SDOCT),利用典型SC光源的多余输出功率,在不损失成像速度的情况下提高系统性能。在我们提出的技术中,SC输出的光通过基于光纤的光缓冲和平均系统,通过对8次SC发射进行平均来提高PSD稳定性。结果表明,尽管成像速度从16.8 kHz提高到91.9 kHz,但经过缓冲和平均后6.96 µs的SC发射可以实现与55.68 µs更长曝光时间相同的PSD稳定性。系统灵敏度提高了8.6 dB,达到100.6 dB,进而改善了结构成像、多普勒OCT速度测量和散斑方差OCT(SVOCT)血管造影成像的信噪比,如模型和实验所示。