Barnes Kerri T, McDowell Bradley D, Button Anna, Smith Brian J, Lynch Charles F, Gupta Amit
Department of Urology, University of Iowa, 200 Hawkins Dr., 3 RCP, Iowa City, IA, 52242-1089, USA.
Holden Comprehensive Cancer Center, University of Iowa, Iowa City, IA, USA.
BMC Urol. 2016 Jul 13;16(1):42. doi: 10.1186/s12894-016-0161-7.
To validate the association between obesity and penile cancer at a population level, we conducted a matched case-control study linking the Iowa Department of Motor Vehicles Drivers' License Database (DLD) with cancer surveillance data collected by the State Health Registry of Iowa (SHRI).
All men diagnosed with invasive penile squamous cell carcinoma from 1985 to 2010 were identified by SHRI. Two hundred sixty-six cancer cases and 816 cancer-free male controls, selected from the Iowa DLD, were matched within 5-year age and calendar year strata. Body mass index (BMI) was calculated using self-reported height and weight from the DLD.
Conditional logistic regression was used to evaluate the association between BMI and the risk of developing invasive penile cancer. Obesity was significantly associated with an increased risk of developing penile cancer. For every five-unit increase in BMI the risk of invasive penile cancer increased by 53 % (OR 1.53, 95 % CI 1.29-1.81, p < 0.0001).
We previously reported an association between obesity and higher risk of invasive penile cancer and advanced cancer stage at diagnosis in a hospital-based retrospective study. This population-based study confirms an association between obesity and invasive penile cancer.
为了在人群层面验证肥胖与阴茎癌之间的关联，我们开展了一项匹配病例对照研究，将爱荷华州机动车驾驶证数据库（DLD）与爱荷华州州立卫生登记处（SHRI）收集的癌症监测数据相链接。
SHRI确定了1985年至2010年期间所有被诊断为浸润性阴茎鳞状细胞癌的男性。从爱荷华州DLD中选取了266例癌症病例和816例无癌男性对照，并在5岁年龄组和日历年分层内进行匹配。使用DLD中自我报告的身高和体重计算体重指数（BMI）。
采用条件逻辑回归评估BMI与发生浸润性阴茎癌风险之间的关联。肥胖与发生阴茎癌风险增加显著相关。BMI每增加5个单位，浸润性阴茎癌风险增加53%（比值比1.53，95%置信区间1.29 - 1.81，p < 0.0001）。
我们之前在一项基于医院的回顾性研究中报告了肥胖与浸润性阴茎癌风险增加以及诊断时癌症晚期之间的关联。这项基于人群的研究证实了肥胖与浸润性阴茎癌之间的关联。
