用于生物成像和药物递送的可清除肾有机纳米载体。
Renal Clearable Organic Nanocarriers for Bioimaging and Drug Delivery.
机构信息
Division of Hematology/Oncology, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, 02215, USA.
Institut Albert Bonniot, Université Grenoble Alpes, Grenoble, F-38000, France.
出版信息
Adv Mater. 2016 Oct;28(37):8162-8168. doi: 10.1002/adma.201601101. Epub 2016 Jul 14.
Abstract
Renally cleared zwitterionic nanocarriers (H-Dots) are composed of ε-polylysine backbone for charge variations, near-infrared fluorophores for bioimaging, and β-cyclodextrins for potential drug delivery. H-Dots show ideal systemic circulation and rapid distribution and excrete from normal tissue/organ via renal excretion after complete targeting to the tumor site without nonspecific uptake by the immune system.
摘要
肾清除两性离子纳米载体 (H-Dots) 由 ε-聚赖氨酸骨架组成，用于电荷变化，近红外荧光团用于生物成像，β-环糊精用于潜在的药物输送。H-Dots 在完全靶向肿瘤部位后，显示出理想的系统循环和快速分布，并通过肾脏排泄从正常组织/器官中快速排出，而不会被免疫系统非特异性摄取。
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本文引用的文献
1
Pharmacokinetics, pharmacodynamics and toxicology of theranostic nanoparticles.诊疗纳米颗粒的药代动力学、药效学及毒理学
Nanoscale. 2015 Dec 7;7(45):18848-62. doi: 10.1039/c5nr05264e. Epub 2015 Nov 3.
2
Clearance Pathways and Tumor Targeting of Imaging Nanoparticles.成像纳米颗粒的清除途径与肿瘤靶向性
ACS Nano. 2015 Jul 28;9(7):6655-74. doi: 10.1021/acsnano.5b01320. Epub 2015 Jul 14.
3
700-nm Zwitterionic Near-Infrared Fluorophores for Dual-Channel Image-Guided Surgery.用于双通道图像引导手术的700纳米两性离子近红外荧光团
Mol Imaging Biol. 2016 Feb;18(1):52-61. doi: 10.1007/s11307-015-0870-4.
4
Effect of the surface modification, size, and shape on cellular uptake of nanoparticles.表面修饰、尺寸和形状对纳米颗粒细胞摄取的影响。
Cell Biol Int. 2015 Aug;39(8):881-90. doi: 10.1002/cbin.10459. Epub 2015 Apr 29.
5
Target-specific near-IR induced drug release and photothermal therapy with accumulated Au/Ag hollow nanoshells on pulmonary cancer cell membranes.基于肺癌细胞膜上 Au/Ag 中空纳米壳的靶向近红外光诱导药物释放和光热治疗。
Biomaterials. 2015 Mar;45:81-92. doi: 10.1016/j.biomaterials.2014.12.036. Epub 2015 Jan 16.
6
Central C-C Bonding Increases Optical and Chemical Stability of NIR Fluorophores.中心碳-碳键增强近红外荧光团的光学和化学稳定性。
RSC Adv. 2014 Jan 1;4(102):58762-58768. doi: 10.1039/C4RA11225C.
7
Theranostic nanoparticles.诊疗纳米颗粒。
J Nucl Med. 2014 Dec;55(12):1919-22. doi: 10.2967/jnumed.114.146019. Epub 2014 Nov 20.
8
Clinical translation of an ultrasmall inorganic optical-PET imaging nanoparticle probe.一种超小型无机光学-正电子发射断层成像纳米粒子探针的临床转化
Sci Transl Med. 2014 Oct 29;6(260):260ra149. doi: 10.1126/scitranslmed.3009524.
9
Self-assembled micellar nanocomplexes comprising green tea catechin derivatives and protein drugs for cancer therapy.用于癌症治疗的由绿茶儿茶素衍生物和蛋白质药物组成的自组装胶束纳米复合物。
Nat Nanotechnol. 2014 Nov;9(11):907-912. doi: 10.1038/nnano.2014.208. Epub 2014 Oct 5.
10
A smart and versatile theranostic nanomedicine platform based on nanoporphyrin.一种基于纳米卟啉的智能多功能诊疗纳米医学平台。
Nat Commun. 2014 Aug 26;5:4712. doi: 10.1038/ncomms5712.
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