摄食行为与脑室注射前列腺素 E1 引起的交感神经激活有关。

Eating Behavior is Associated to Sympathetic Activation Induced by ICV Injection of Prostaglandin E1 in the Rat.

机构信息

a Department of Human Physiology and Integrated Biological Functions , "Filippo Bottazzi", Second University of Naples , Via Costantinopoli 16, 80138 Naples , Italy.

出版信息

Nutr Neurosci. 1999;2(2):69-74. doi: 10.1080/1028415X.1999.11747264.

DOI:10.1080/1028415X.1999.11747264

PMID:27414965

Abstract

This experiment tests the effect of intracerebro-ventricular (icv) injection of prostaglandin E1 (PGE1) on. (1) food intake, (2) sympathetic activity and body temperature. The firing rate of the sympathetic nerves to interscapular brown adipose tissue (IBAT), along with IBAT and colonic temperatures (TIBAT and TC) were monitored in male Sprague-Dawley rats before and for 90 min after food presentation. An icv injection of PGE1 (500 ng) or saline was made immediately before food presentation. The amount of food ingested was also measured. The same procedure was carried out in control rats without food presentation. The results show that PGE1 raises the sympathetic firing rate, TIBAT and TC and it causes a decrease in food intake. These findings suggest that the food intake is associated to the sympathetic activity in the PGE1-hyperthermia.

摘要

本实验测试了脑室内（icv）注射前列腺素 E1（PGE1）对以下方面的影响：（1）摄食，（2）交感神经活动和体温。在雄性 Sprague-Dawley 大鼠中，在食物呈现之前和之后的 90 分钟内，监测了肩胛间棕色脂肪组织（IBAT）的交感神经放电率，以及 IBAT 和结肠温度（TIBAT 和 TC）。在食物呈现之前，立即进行 PGE1（500ng）或盐水的 icv 注射。还测量了摄入的食物量。在没有食物呈现的对照大鼠中进行了相同的程序。结果表明，PGE1 提高了交感神经放电率、TIBAT 和 TC，并导致食物摄入量减少。这些发现表明，在 PGE1 发热中，食物摄入与交感神经活动有关。