Monda M, Sullo A, De Luca E, Pellicano M P
Dipartimento di Fisiologia Umana e Funzioni Biologiche Integrate Filippo Bottazzi, Seconda Università di Napoli, Italy.
Am J Physiol. 1996 Dec;271(6 Pt 2):R1638-42. doi: 10.1152/ajpregu.1996.271.6.R1638.
These experiments test the effect of intraperitoneal injection of lysine acetylsalicylate on 1) food intake and 2) the sympathetic and thermogenic changes induced by lesion of the lateral hypothalamus (LH). Food intake, firing rate of the nerves innervating interscapular brown adipose tissue (IBAT), and IBAT and colonic temperatures (TIBAT and TC) were monitored in male Sprague-Dawley rats lesioned in the LH. These variables were measured before and after intraperitoneal injection of lysine acetylsalicylate. The same variables were also monitored in 1) lesioned rats with intraperitoneal administration of saline, 2) sham-lesioned animals with intraperitoneal injection of lysine acetylsalicylate, and 3) sham-lesioned rats with intraperitoneal injection of saline. The results show that lysine acetylsalicylate modifies the aphagia by increasing food intake and also reduces the enhancements in firing rate, TIBAT, and TC induced by LH lesion. These findings suggest that prostaglandin synthesis plays a key role in the control of eating behavior in LH-lesioned rats by acting on the sympathetic and thermogenic changes induced by LH lesion.
1）食物摄入量；2）下丘脑外侧区（LH）损伤所诱导的交感神经和产热变化。在LH损伤的雄性Sprague-Dawley大鼠中监测食物摄入量、支配肩胛间棕色脂肪组织（IBAT）的神经放电频率以及IBAT和结肠温度（TIBAT和TC）。在腹腔注射赖氨酸乙酰水杨酸酯之前和之后测量这些变量。同样的变量也在以下三组中进行监测：1）腹腔注射生理盐水的损伤大鼠；2）腹腔注射赖氨酸乙酰水杨酸酯的假损伤动物；3）腹腔注射生理盐水的假损伤大鼠。结果表明，赖氨酸乙酰水杨酸酯通过增加食物摄入量来改变摄食不能，并且还减少了由LH损伤所诱导的放电频率、TIBAT和TC的升高。这些发现表明，前列腺素合成通过作用于LH损伤所诱导的交感神经和产热变化，在LH损伤大鼠的进食行为控制中起关键作用。
