Vengerovskii A I, Yakimova T V, Nasanova O N
Eksp Klin Farmakol. 2016;79(2):29-33.
Experiments on rats with diabetes mellitus model induced by streptosotocin and high (30%) fat diet showed that the daily treatment with aqueous extracts of great nettle leaves (100 mg/kg) and common burdock roots (25 mg/kg) for a period of 10 days led to a decrease in the glycemic index and triglyceride level and produced protective action on erythrocytes both in animals kept on a fat-rich diet and on the background of a low-caloric ration. Both medicinal plant extracts were comparable with reference drug metformin in reducing the concentration of glycosylated hemoglobin (by 12-31%) and ectoglobular hemoglobin (1.7-1.8 times, p <0.05), decreasing the content of malonic dialdehyde in erythrocytes (1.3 times, p < 0.05), and increasing erythrocyte deformability (1.3-1.4 times, p < 0.05) and activity of their antioxidant enzymes glutathione peroxidase, glutathione reductase, glutathione-S-transferase, catalase, and supe- roxide dismutase (1.2-2.6 times, p < 0.05). A diet with usual (8%) fat content improved the metabolic indices to a lower degree (on the average by 13-21%, p < 0.05) than did the proposed phytotherapy.
对用链脲佐菌素和高（30%）脂肪饮食诱导的糖尿病大鼠模型进行的实验表明，每天用大荨麻叶水提取物（100毫克/千克）和牛蒡根水提取物（25毫克/千克）处理10天，可使血糖指数和甘油三酯水平降低，并对食用高脂肪饮食的动物以及低热量饮食背景下的动物的红细胞产生保护作用。在降低糖化血红蛋白浓度（降低12 - 31%）和细胞外血红蛋白浓度（降低1.7 - 1.8倍，p < 0.05）、降低红细胞中丙二醛含量（降低1.3倍，p < 0.05）、增加红细胞变形性（增加1.3 - 1.4倍，p < 0.05）以及增加其抗氧化酶谷胱甘肽过氧化物酶、谷胱甘肽还原酶、谷胱甘肽 - S - 转移酶、过氧化氢酶和超氧化物歧化酶的活性（增加1.2 - 2.6倍，p < 0.05）方面，两种药用植物提取物与参比药物二甲双胍相当。脂肪含量正常（8%）的饮食改善代谢指标的程度（平均降低13 - 21%，p < 0.05）低于所提议的植物疗法。
