Joukar Siyavash
Physiology Research Center, Kerman University of Medical Sciences, Kerman, Iran; Department of Physiology and Pharmacology, Kerman University of Medical Sciences, Kerman, Iran.
EXCLI J. 2012 Aug 17;11:480-6. eCollection 2012.
Considering the global popularity and also the various biological and medicinal properties of saffron, this study was conducted to assess the influence of its aqueous extracts administration on blood pressure, pressure-rate product (PRP) and electrocardiogram (ECG) indices of rat. Animals were divided to control (CTL), SAF50, SAF100, and SAF200 groups that orally received tap water, aqueous extracts of saffron 50, 100 and 200 mg/kg/day respectively for seven days. On day 8, data were recorded. Different doses of saffron had no significant effect on blood pressure and also PRP. Higher dose (200 mg/kg) of saffron significantly increased the PR interval, P duration, QT interval (p<0.01), QRS interval, QTcn (normalized corrected QT) (p<0.001), and JT interval (p<0.05) of ECG compared to the CTL group. In addition, the two other doses only significantly prolonged the QT, QTcn and JT intervals of ECG versus the CTL group. The SAF200 group also showed a notable increase in RR interval which only was significant versus to the SAF50. There was no significant difference among ST height and T amplitude ranges of different groups. The results suggest that high dose of saffron definitely slows the electrical conduction velocity in both atrium and ventricle.
鉴于藏红花在全球的广泛应用及其多种生物学和药用特性，本研究旨在评估给予大鼠藏红花水提取物对其血压、压力 - 心率乘积（PRP）和心电图（ECG）指标的影响。将动物分为对照组（CTL）、SAF50组、SAF100组和SAF200组，分别连续7天口服自来水、50、100和200 mg/kg/天的藏红花水提取物。在第8天记录数据。不同剂量的藏红花对血压和PRP均无显著影响。与CTL组相比，高剂量（200 mg/kg）的藏红花显著增加了心电图的PR间期、P波时限、QT间期（p<0.01）、QRS间期、QTcn（标准化校正QT）（p<0.001）和JT间期（p<0.05）。此外，与CTL组相比，另外两个剂量仅显著延长了心电图的QT、QTcn和JT间期。SAF200组的RR间期也显著增加，仅与SAF50组相比有显著差异。不同组的ST段高度和T波振幅范围之间无显著差异。结果表明，高剂量的藏红花肯定会减慢心房和心室的电传导速度。
