• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

利用新型壳聚糖微胶囊进行体内磁共振成像和微波热疗癌症。

In Vivo Magnetic Resonance Imaging and Microwave Thermotherapy of Cancer Using Novel Chitosan Microcapsules.

机构信息

Department of Radiology, the First Hospital of China Medical University, No. 155 Nanjing North Road, Shenyang, 110001, People's Republic of China.

Laboratory of Controllable Preparation and Application of Nanomaterials, Center for Micro/Nanomaterials and Technology and Key Laboratory of Photochemical Conversion and Optoelectronic Materials, Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing, 100190, China.

出版信息

Nanoscale Res Lett. 2016 Dec;11(1):334. doi: 10.1186/s11671-016-1536-0. Epub 2016 Jul 15.

DOI:10.1186/s11671-016-1536-0
PMID:27422776
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4947076/
Abstract

Herein, we develop a novel integrated strategy for the preparation of theranostic chitosan microcapsules by encapsulating ion liquids (ILs) and Fe3O4 nanoparticles. The as-prepared chitosan/Fe3O4@IL microcapsules exhibit not only significant heating efficacy in vitro under microwave (MW) irradiation but also obvious enhancement of T2-weighted magnetic resonance (MR) imaging, besides the excellent biocompatibility in physiological environments. The chitosan/Fe3O4@IL microcapsules show ideal temperature rise and therapeutic efficiency when applied to microwave thermal therapy in vivo. Complete tumor elimination is realizing after MW irradiation at an ultralow power density (1.8 W/cm(2)), while neither the MW group nor the chitosan microcapsule group has significant influence on the tumor development. The applicability of the chitosan/Fe3O4@IL microcapsules as an efficient contrast agent for MR imaging is proved in vivo. Moreover, the result of in vivo systematic toxicity shows that chitosan/Fe3O4@IL microcapsules have no acute fatal toxicity. Our study presents an interesting type of multifunctional platform developed by chitosan microcapsule promising for imaging-guided MW thermotherapy.

摘要

在此，我们开发了一种新颖的综合策略，用于制备治疗性壳聚糖微胶囊，方法是封装离子液体 (IL) 和 Fe3O4 纳米粒子。所制备的壳聚糖/Fe3O4@IL 微胶囊不仅在微波 (MW) 照射下具有显著的体外加热效果，而且在生理环境下还具有优异的生物相容性，同时还明显增强了 T2 加权磁共振 (MR) 成像。壳聚糖/Fe3O4@IL 微胶囊在体内微波热疗中应用时，表现出理想的温升和治疗效果。在超低功率密度 (1.8 W/cm(2)) 下进行 MW 照射后可实现完全消除肿瘤，而 MW 组和壳聚糖微胶囊组对肿瘤的发展均无明显影响。体内研究证明了壳聚糖/Fe3O4@IL 微胶囊作为一种高效磁共振成像对比剂的适用性。此外，体内系统毒性研究结果表明，壳聚糖/Fe3O4@IL 微胶囊无急性致命毒性。我们的研究提出了一种有趣的多功能平台，由壳聚糖微胶囊开发，有望用于成像引导的 MW 热疗。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/81a5/4947076/0da116cc15fc/11671_2016_1536_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/81a5/4947076/2a9d1c0ee411/11671_2016_1536_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/81a5/4947076/fff508f0450d/11671_2016_1536_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/81a5/4947076/bba78b7d451a/11671_2016_1536_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/81a5/4947076/b911d1722de4/11671_2016_1536_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/81a5/4947076/0da116cc15fc/11671_2016_1536_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/81a5/4947076/2a9d1c0ee411/11671_2016_1536_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/81a5/4947076/fff508f0450d/11671_2016_1536_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/81a5/4947076/bba78b7d451a/11671_2016_1536_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/81a5/4947076/b911d1722de4/11671_2016_1536_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/81a5/4947076/0da116cc15fc/11671_2016_1536_Fig5_HTML.jpg

相似文献

1
In Vivo Magnetic Resonance Imaging and Microwave Thermotherapy of Cancer Using Novel Chitosan Microcapsules.利用新型壳聚糖微胶囊进行体内磁共振成像和微波热疗癌症。
Nanoscale Res Lett. 2016 Dec;11(1):334. doi: 10.1186/s11671-016-1536-0. Epub 2016 Jul 15.
2
Encapsulating Ionic Liquid and Fe₃O₄ Nanoparticles in Gelatin Microcapsules as Microwave Susceptible Agent for MR Imaging-guided Tumor Thermotherapy.将离子液体和Fe₃O₄纳米颗粒封装在明胶微胶囊中作为用于磁共振成像引导肿瘤热疗的微波敏感剂。
ACS Appl Mater Interfaces. 2015 Jun 24;7(24):13612-9. doi: 10.1021/acsami.5b03230. Epub 2015 Jun 10.
3
Imaging-guided synergetic therapy of orthotopic transplantation tumor by superselectively arterial administration of microwave-induced microcapsules.经超选择性动脉内注入微波诱导微囊行影像引导协同治疗荷移植瘤
Biomaterials. 2017 Jul;133:144-153. doi: 10.1016/j.biomaterials.2017.04.027. Epub 2017 Apr 14.
4
Evaluation of superparamagnetic iron oxide-polymer composite microcapsules for magnetic resonance-guided high-intensity focused ultrasound cancer surgery.用于磁共振引导高强度聚焦超声癌症手术的超顺磁性氧化铁-聚合物复合微胶囊的评估
BMC Cancer. 2014 Nov 3;14:800. doi: 10.1186/1471-2407-14-800.
5
Drug-Loaded Magnetic Microhydrogel as Microwave Susceptible Agents for Cancer Multimodality Treatment and MR Imaging.载药磁性微水凝胶作为癌症多模态治疗和磁共振成像的微波敏感器材。
J Biomed Nanotechnol. 2018 Feb 1;14(2):362-370. doi: 10.1166/jbn.2018.2511.
6
Magnetic separable chitosan microcapsules decorated with silver nanoparticles for catalytic reduction of 4-nitrophenol.磁性可分离壳聚糖微胶囊负载纳米银用于催化还原 4-硝基苯酚。
J Colloid Interface Sci. 2017 Dec 1;507:353-359. doi: 10.1016/j.jcis.2017.08.014. Epub 2017 Aug 5.
7
Biocompatible Hollow Polydopamine Nanoparticles Loaded Ionic Liquid Enhanced Tumor Microwave Thermal Ablation in Vivo.负载离子液体的生物相容性中空聚多巴胺纳米颗粒增强体内肿瘤微波热消融
ACS Appl Mater Interfaces. 2016 May 11;8(18):11237-45. doi: 10.1021/acsami.5b12329. Epub 2016 Apr 27.
8
Imaging guided photothermal therapy using iron oxide loaded poly(lactic acid) microcapsules coated with graphene oxide.使用负载氧化铁的聚乳酸微胶囊并涂覆氧化石墨烯的成像引导光热疗法。
J Mater Chem B. 2014 Jan 14;2(2):217-223. doi: 10.1039/c3tb21281e. Epub 2013 Nov 25.
9
Multisynergistic Platform for Tumor Therapy by Mild Microwave Irradiation-Activated Chemotherapy and Enhanced Ablation.用于肿瘤治疗的多协同平台：温和微波辐射激活化疗与增强消融
ACS Nano. 2016 Oct 25;10(10):9516-9528. doi: 10.1021/acsnano.6b04749. Epub 2016 Oct 5.
10
In situ preparation of magnetic Fe3O4 nanoparticles inside nanoporous poly(L-glutamic acid)/chitosan microcapsules for drug delivery.在纳米多孔聚（L-谷氨酸）/壳聚糖微胶囊内原位制备用于药物输送的磁性 Fe3O4 纳米粒子。
Colloids Surf B Biointerfaces. 2014 Jan 1;113:302-11. doi: 10.1016/j.colsurfb.2013.09.004. Epub 2013 Sep 23.

引用本文的文献

1
Recent advances in surface modification of micro- and nano-scale biomaterials with biological membranes and biomolecules.微纳尺度生物材料与生物膜和生物分子的表面修饰研究进展
Front Bioeng Biotechnol. 2022 Oct 12;10:972790. doi: 10.3389/fbioe.2022.972790. eCollection 2022.
2
Applications of phase change materials in smart drug delivery for cancer treatment.相变材料在癌症治疗智能药物递送中的应用。
Front Bioeng Biotechnol. 2022 Sep 12;10:991005. doi: 10.3389/fbioe.2022.991005. eCollection 2022.
3
Smart magnetic resonance imaging-based theranostics for cancer.

本文引用的文献

1
Layered MoS nanoflowers for microwave thermal therapy.用于微波热疗的层状二硫化钼纳米花
J Mater Chem B. 2016 Mar 28;4(12):2133-2141. doi: 10.1039/c6tb00296j. Epub 2016 Mar 2.
2
Highly stable microwave susceptible agents via encapsulation of Ti-mineral superfine powders in urea-formaldehyde resin microcapsules for tumor hyperthermia therapy.通过将 Ti 矿物超细粉末封装在脲醛树脂微胶囊中制备高稳定性的微波敏感剂用于肿瘤热疗。
Nanoscale. 2016 Jun 7;8(21):11044-51. doi: 10.1039/c6nr01597b. Epub 2016 May 13.
3
Biocompatible Hollow Polydopamine Nanoparticles Loaded Ionic Liquid Enhanced Tumor Microwave Thermal Ablation in Vivo.
基于智能磁共振成像的癌症诊疗一体化。
Theranostics. 2021 Aug 7;11(18):8706-8737. doi: 10.7150/thno.57004. eCollection 2021.
4
An ultra wideband-high spatial resolution-compact electric field sensor based on Lab-on-Fiber technology.一种基于光纤实验室技术的超宽带、高空间分辨率、紧凑型电场传感器。
Sci Rep. 2019 May 30;9(1):8058. doi: 10.1038/s41598-019-44644-y.
5
Surface Modification of Magnetic Iron Oxide Nanoparticles.磁性氧化铁纳米颗粒的表面改性
Nanomaterials (Basel). 2018 Oct 9;8(10):810. doi: 10.3390/nano8100810.
6
A novel EGFR-TKI inhibitor (cAMP-HBOcomplex) combined with thermal therapy is a promising strategy to improve lung cancer treatment outcomes.一种新型表皮生长因子受体酪氨酸激酶抑制剂（环磷酸腺苷-高压氧复合物）联合热疗是改善肺癌治疗效果的一种有前景的策略。
Oncotarget. 2017 May 5;8(34):56327-56337. doi: 10.18632/oncotarget.17628. eCollection 2017 Aug 22.
负载离子液体的生物相容性中空聚多巴胺纳米颗粒增强体内肿瘤微波热消融
ACS Appl Mater Interfaces. 2016 May 11;8(18):11237-45. doi: 10.1021/acsami.5b12329. Epub 2016 Apr 27.
4
Cell selective chitosan microparticles as injectable cell carriers for tissue regeneration.细胞选择性壳聚糖微球作为组织再生的可注射细胞载体。
Biomaterials. 2015 Mar;43:23-31. doi: 10.1016/j.biomaterials.2014.11.047. Epub 2014 Dec 23.
5
Microwave synthesis of microstructured and nanostructured metal chalcogenides from elemental precursors in phosphonium ionic liquids.在鏻离子液体中从元素前体制备微结构和纳米结构的金属硫属化物的微波合成。
J Am Chem Soc. 2014 Nov 5;136(44):15465-8. doi: 10.1021/ja508628q. Epub 2014 Oct 21.
6
Rapid conversion of sorbitol to isosorbide in hydrophobic ionic liquids under microwave irradiation.微波辐射下疏水离子液体中 sorbitol 快速转化为异山梨醇
ChemSusChem. 2014 Dec;7(12):3257-9. doi: 10.1002/cssc.201402655. Epub 2014 Sep 15.
7
Heparin-chitosan nanoparticle functionalization of porous poly(ethylene glycol) hydrogels for localized lentivirus delivery of angiogenic factors.用于血管生成因子局部慢病毒递送的多孔聚乙二醇水凝胶的肝素-壳聚糖纳米颗粒功能化
Biomaterials. 2014 Oct;35(30):8687-93. doi: 10.1016/j.biomaterials.2014.06.027. Epub 2014 Jul 11.
8
Ionic liquids for energy, materials, and medicine.用于能源、材料和医学的离子液体。
Chem Commun (Camb). 2014 Aug 25;50(66):9228-50. doi: 10.1039/c4cc02021a.
9
CoFe2O4 and/or Co3Fe7 loaded porous activated carbon balls as a lightweight microwave absorbent.负载CoFe2O4和/或Co3Fe7的多孔活性炭球作为一种轻质微波吸收剂。
Phys Chem Chem Phys. 2014 Jun 28;16(24):12385-92. doi: 10.1039/c4cp00647j.
10
Uptake, transport and peroral absorption of fatty glyceride grafted chitosan copolymer-enoxaparin nanocomplexes: influence of glyceride chain length.脂肪甘油酯接枝壳聚糖共聚物-依诺肝素纳米复合物的摄取、转运和口服吸收：甘油酯链长的影响。
Acta Biomater. 2014 Aug;10(8):3675-85. doi: 10.1016/j.actbio.2014.05.003. Epub 2014 May 9.