Wang Shengping, Tan Longfei, Liang Ping, Liu Tianlong, Wang Jingzhuo, Fu Changhui, Yu Jie, Dou Jianping, Li Hong, Meng Xianwei
Department of Materials Science and Engineering, Jinan University, Guangzhou, 510632, P. R. China.
J Mater Chem B. 2016 Mar 28;4(12):2133-2141. doi: 10.1039/c6tb00296j. Epub 2016 Mar 2.
Microwave (MW) hyperthermia has received great attention as an emerging green tumor thermotherapy. In this work, layered MoS nanoflowers were prepared through a simple bottom-up hydrothermal process. By coating MoS nanoflowers with bovine serum albumin (BSA-MoS), BSA-MoS exhibits low biotoxicity and excellent microwave susceptive properties in vitro. Meanwhile, the heating effect improvement by the layered structure was confirmed via a computer-simulated experiment. Finally, layered BSA-MoS nanoflowers are designed as MW hyperthermia susceptible agents for in vivo cancer therapy with 100% tumor elimination via MW irradiation at 1.8 W, 450 MHz.
微波（MW）热疗作为一种新兴的绿色肿瘤热疗法受到了广泛关注。在这项工作中，通过简单的自下而上水热法制备了层状二硫化钼纳米花。通过用牛血清白蛋白包覆二硫化钼纳米花（BSA-MoS），BSA-MoS在体外表现出低生物毒性和优异的微波敏感特性。同时，通过计算机模拟实验证实了层状结构对加热效果的改善。最后，层状BSA-MoS纳米花被设计为用于体内癌症治疗的微波热疗敏感剂，在1.8 W、450 MHz的微波照射下可实现100%消除肿瘤。
