CICS-UBI, Health Sciences Research Centre, University of Beira Interior, Covilhã, Portugal.
Environ Int. 2016 Sep;94:758-776. doi: 10.1016/j.envint.2016.07.004.
Every year millions of tons of plastic are produced around the world and humans are increasingly exposed to them. This constant exposure to plastics has raised some concerns against human health, particularly when it comes to phthalates. These compounds have endocrine-disrupting properties, as they have the ability to bind molecular targets in the body and interfere with hormonal function and quantity. The main use of phthalates is to give flexibility to polyvinyl chloride (PVC) polymers. Phthalates are found in a variety of industrial and consumer products, and as they are not covalently bound to the plastic, phthalates contaminate the environment from which human exposure occurs. Studies in human and animal populations suggest a correlation between phthalate exposure and adverse health outcomes, particularly at the reproductive and cardiovascular systems, however there is much less information about the phthalate toxicity of the later. Thus, the main purpose of this review is to present the studies relating the effects already stated of phthalates on the cardiovascular and reproductive systems, and also present the link between these two systems.
每年全世界都有数百万吨塑料被生产出来，人类也越来越多地接触到它们。这种持续的塑料暴露引起了一些对人类健康的担忧，特别是当涉及到邻苯二甲酸酯时。这些化合物具有内分泌干扰特性，因为它们能够结合体内的分子靶标并干扰激素功能和数量。邻苯二甲酸酯的主要用途是赋予聚氯乙烯（PVC）聚合物柔韧性。邻苯二甲酸酯存在于各种工业和消费产品中，由于它们与塑料没有共价结合，因此邻苯二甲酸酯会污染人类暴露于其中的环境。在人类和动物群体中的研究表明，邻苯二甲酸酯暴露与不良健康结果之间存在相关性，特别是在生殖和心血管系统中，但关于后者的邻苯二甲酸酯毒性的信息要少得多。因此，本综述的主要目的是介绍已经表明邻苯二甲酸酯对心血管和生殖系统的影响的研究，并介绍这两个系统之间的联系。
