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使用润滑剂、眼睑卫生护理和眼部营养补充剂组合缓解干眼体征和症状。

The relief of dry eye signs and symptoms using a combination of lubricants, lid hygiene and ocular nutraceuticals.

作者信息

Ngo William, Srinivasan Sruthi, Houtman Diane, Jones Lyndon

机构信息

Centre for Contact Lens Research, University of Waterloo School of Optometry & Vision Science, Waterloo, Ontario, Canada.

Centre for Contact Lens Research, University of Waterloo School of Optometry & Vision Science, Waterloo, Ontario, Canada.

出版信息

J Optom. 2017 Jan-Mar;10(1):26-33. doi: 10.1016/j.optom.2016.05.001. Epub 2016 Jul 12.

DOI:10.1016/j.optom.2016.05.001
PMID:27425263
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5219834/
Abstract

PURPOSE

To determine the combined effect of TheraTears Lubricant Eye Drops, TheraTears SteriLid Eyelid Cleanser, and TheraTears Nutrition on dry eye signs and symptoms.

METHODS

This prospective study enrolled 28 dry eye participants. Participants were instructed to use the Lubricant Eye Drops at least 2-4× a day, SteriLid 1-2× a day, and Nutrition 3 gel caps once a day. Participants were followed up at baseline, 1 month and 3 months. Outcome variables were the Ocular Surface Disease Index (OSDI), Symptom Assessment iN Dry Eye (SANDE) questionnaire, non-invasive tear break-up time (NIBUT), osmolarity, number of meibomian glands blocked (#MG blocked), meibum quality, eyelid margin features, Schirmer's test, tear film lipid layer thickness (LLT), meniscus height, corneal and conjunctival staining.

RESULTS

Twenty participants (mean age=43, from 23 to 66, 17F, 3M) completed the study. Participants reported having used, on average, the Lubricant Eye Drop 2.4×/day, the SteriLid 1.1×/day, and the Nutrition 3 gel caps 1×/day. There was a significant change over time (p<0.05) for OSDI (-21.2 points), SANDE (-32.4 points), NIBUT (+0.43s), eyelid margin features (-1.1 grade), meibum quality (-1.0 grade), and #MG blocked (-4.0 glands).

CONCLUSION

By using a combination of TheraTears Lubricant Eye Drop, SteriLid, and Nutrition, patients experience significant relief in both dry eye symptoms and signs.

摘要

目的

确定泪然润滑滴眼液、泪然无菌眼睑清洁剂和泪然营养剂对干眼体征和症状的综合影响。

方法

这项前瞻性研究招募了28名干眼参与者。参与者被指导每天至少使用2 - 4次润滑滴眼液，每天使用1 - 2次无菌眼睑清洁剂，每天服用3粒营养剂胶囊。在基线、1个月和3个月时对参与者进行随访。观察指标包括眼表疾病指数（OSDI）、干眼症状评估（SANDE）问卷、非侵入性泪膜破裂时间（NIBUT）、渗透压、睑板腺堵塞数量（#MG堵塞）、睑脂质量、睑缘特征、Schirmer试验、泪膜脂质层厚度（LLT）、泪河高度、角膜和结膜染色。

结果

20名参与者（平均年龄 = 43岁，年龄范围23至66岁，17名女性，3名男性）完成了研究。参与者报告平均每天使用润滑滴眼液2.4次，无菌眼睑清洁剂1.1次，营养剂胶囊1次。OSDI（-21.2分）、SANDE（-32.4分）、NIBUT（+0.43秒）、睑缘特征（-1.1级）、睑脂质量（-1.0级）和#MG堵塞（-4.0个腺体）随时间有显著变化（p<0.05）。

结论

通过联合使用泪然润滑滴眼液、无菌眼睑清洁剂和营养剂，患者的干眼症状和体征得到显著缓解。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7202/5219834/c083df21a057/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7202/5219834/1a6a6ff91b81/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7202/5219834/f4c4dc02ae32/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7202/5219834/1849daeb3dec/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7202/5219834/c083df21a057/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7202/5219834/1a6a6ff91b81/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7202/5219834/f4c4dc02ae32/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7202/5219834/1849daeb3dec/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7202/5219834/c083df21a057/gr4.jpg

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