Yilmaz A, Tumkaya L, Akyildiz K, Kalkan Y, Bodur A F, Sargin F, Efe H, Uydu H A, Yazici Z A
a Department of Biochemistry.
b Department of Histology & Embryology , and.
J Matern Fetal Neonatal Med. 2017 Jun;30(11):1355-1359. doi: 10.1080/14767058.2016.1214124. Epub 2016 Aug 10.
In this study, the livers of rats born to mothers exposed to electromagnetic field (EMF) were examined 60 days postpartum for biochemical and histopathological changes.
Pregnant rats were exposed to radiation (900 MHz EMF, 24 h/day for 20 days) using a digital signal generator by placing the device centrally under the cage, which formed the study (EMF) group, while untreated matching rats served as controls. Livers and blood were obtained from litters (seven males and seven females) of both groups 60 days after birth, which were used for biochemical and histopathological analyses.
There was a significant increase in the levels of malondialdehyde (MDA) (p < 0.05) that was accompanied by a significant fall in glutathione (GSH) (p < 0.01) in the liver. The serum levels of alanine aminotransferase (ALT) and aspartate aminotransferase (AST) were significantly increased (p < 0.05). Histopathologically, the liver sections of the EMF group showed intense degeneration in hepatocytes with cytoplasmic eosinophilic structures, pyknotic nuclei and fibrosis.
We demonstrate that the intrauterin harmful effects of EMF on the livers of rats persist into adulthood.
在本研究中，对暴露于电磁场（EMF）的母鼠所生大鼠产后60天的肝脏进行生化和组织病理学变化检查。
使用数字信号发生器，将怀孕大鼠置于笼子中央下方，使其暴露于辐射（900 MHz电磁场，每天24小时，共20天），该组构成研究（EMF）组，未处理的配对大鼠作为对照。出生60天后从两组的幼崽（7只雄性和7只雌性）获取肝脏和血液，用于生化和组织病理学分析。
肝脏中丙二醛（MDA）水平显著升高（p < 0.05），同时谷胱甘肽（GSH）显著下降（p < 0.01）。血清丙氨酸转氨酶（ALT）和天冬氨酸转氨酶（AST）水平显著升高（p < 0.05）。组织病理学上，EMF组肝脏切片显示肝细胞有强烈变性，伴有细胞质嗜酸性结构、核固缩和纤维化。
我们证明了电磁场对大鼠肝脏的子宫内有害影响持续至成年期。
