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二甲基二氮杂芘二价阳离子与核酸的相互作用。1. 与核酸组分及单链多核苷酸的结合以及单链寡核苷酸的光裂解

Interactions of the dimethyldiazaperopyrenium dication with nucleic acids. 1. Binding to nucleic acid components and to single-stranded polynucleotides and photocleavage of single-stranded oligonucleotides.

作者信息

Slama-Schwok A, Jazwinski J, Béré A, Montenay-Garestier T, Rougée M, Hélène C, Lehn J M

机构信息

Chimie des Interactions Moléculaires, Collège de France, Paris.

出版信息

Biochemistry. 1989 Apr 18;28(8):3227-34. doi: 10.1021/bi00434a017.

DOI:10.1021/bi00434a017
PMID:2742835
Abstract

The binding of dimethyldiazaperopyrenium dication (1) with nucleosides, nucleotides, and single-stranded polynucleotides has been studied by photophysical methods. It has been shown that 1 may be a potential selective fluorescent probe for A- and/or T-rich polynucleotides. 1 efficiently cleaves oligonucleotides at guanine sites, under illumination with visible light, and therefore may be used as a sequence-specific artificial photonuclease.

摘要

通过光物理方法研究了二甲基二氮杂芘二价阳离子（1）与核苷、核苷酸和单链多核苷酸的结合。结果表明，1可能是一种潜在的用于富含A和/或T的多核苷酸的选择性荧光探针。在可见光照射下，1能在鸟嘌呤位点高效切割寡核苷酸，因此可作为一种序列特异性人工光核酸酶。

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