Quan Qi, Chang Biao, Meng Hao Ye, Liu Ruo Xi, Wang Yu, Lu Shi Bi, Peng Jiang, Zhao Qing
Rev Neurosci. 2016 Oct 1;27(7):761-768. doi: 10.1515/revneuro-2016-0032.
A number of limitations associated with the use of hollow nerve guidance conduits (NGCs) require further discussion. Most importantly, the functional recovery outcomes after the placement of hollow NGCs are poor even after the successful bridging of peripheral nerve injuries. However, nerve regeneration scaffolds built using electric spinning have several advantages that may improve functional recovery. Thus, the present study summarizes recent developments in this area, including the key cells that are combined with the scaffold and associated with nerve regeneration, the structure and configuration of the electrospinning design (which determines the performance of the electrospinning scaffold), the materials the electrospinning fibers are composed of, and the methods used to control the morphology of a single fiber. Additionally, this study also discusses the processes underlying peripheral nerve regeneration. The primary goals of the present review were to evaluate and consolidate the findings of studies that used scaffolding biomaterials built by electrospinning used for peripheral nerve regeneration support. It is amazing that the field of peripheral nerve regeneration continues to consistently produce such a wide variety of innovative techniques and novel types of equipment, because the introduction of every new process creates an opportunity for advances in materials for nerve repair.
与使用中空神经导向导管（NGC）相关的一些局限性需要进一步探讨。最重要的是，即使在外周神经损伤成功桥接后，植入中空NGC后的功能恢复结果仍很差。然而，采用静电纺丝构建的神经再生支架具有一些优势，可能会改善功能恢复。因此，本研究总结了该领域的最新进展，包括与支架结合并与神经再生相关的关键细胞、静电纺丝设计的结构和构型（其决定了静电纺丝支架的性能）、静电纺丝纤维所由的材料以及用于控制单根纤维形态的方法。此外，本研究还讨论了外周神经再生的潜在过程。本综述的主要目的是评估和整合使用通过静电纺丝构建的支架生物材料支持外周神经再生的研究结果。令人惊讶的是，外周神经再生领域不断持续产生如此多种多样的创新技术和新型设备，因为每一个新过程的引入都为神经修复材料的进步创造了机会。
