Daley Peter, Bajgai Janak, Penney Carla, Williams Karen, Whitney Hugh, Golding George R, Weese Scott
Department of Medicine and Laboratory Medicine, Memorial University, Room 1 J421 300 Prince Phillip Dr, St. John's, Newfoundland and Labrador, A1B 3V6, Canada.
Department of Community Health, Memorial University, St. John's, Canada.
BMC Public Health. 2016 Jul 19;16:595. doi: 10.1186/s12889-016-3220-9.
Methicillin-resistant Staphylococcus aureus (MRSA) infections are common among humans in Aboriginal communities in Canada, for unknown reasons.
Cross sectional study of humans and dogs in an Aboriginal community of approximately 1200 persons. Our objectives were to measure community-based prevalence of nasal MRSA colonization among humans, use multivariable logistic regression to analyze risk factors for MRSA colonization, and perform molecular typing of Staphylococci isolated to investigate interspecies transmission.
461 humans were approached for consent and 442 provided complete data. 109/442 (24.7 %, 95 % C.I. = 20.7-28.7 %) of humans were colonized with MRSA. 169/442 (38.2 %) of humans had received antibiotics in the last 12 months. Only number of rooms in the house (OR 0.86, p = 0.023) and recreational dog use (OR 7.7, p = 0.002) were significant risk factors for MRSA colonization. 95/109 (87.1 %) of MRSA strains from humans were of the same spa type (CMRSA10/USA300). 8/157 (5.1 %, 95 % C.I. = 1.7-8.5 %) of dogs were colonized with methicillin-susceptible S. aureus, and no dogs were colonized with MRSA.
Human MRSA colonization in this community is very common, and a single clone is predominant, suggesting local transmission. Antibiotic use is also very common. Crowding may partially explain high colonization, but most considered risk factors including animal exposure were not predictive. Very few dogs carried human Staphylococcal strains.
耐甲氧西林金黄色葡萄球菌（MRSA）感染在加拿大原住民社区的人群中很常见，原因不明。
对一个约有1200人的原住民社区中的人和狗进行横断面研究。我们的目标是测量社区人群中鼻腔MRSA定植的患病率，使用多变量逻辑回归分析MRSA定植的危险因素，并对分离出的葡萄球菌进行分子分型以调查种间传播。
461人被征求同意，442人提供了完整数据。109/442（24.7%，95%置信区间=20.7-28.7%）的人被MRSA定植。169/442（38.2%）的人在过去12个月内接受过抗生素治疗。房屋房间数量（比值比0.86，p=0.023）和娱乐性养狗（比值比7.7，p=0.002）是MRSA定植的显著危险因素。95/109（87.1%）来自人类的MRSA菌株属于同一spa型（CMRSA10/USA300）。8/157（5.1%，95%置信区间=1.7-8.5%）的狗被甲氧西林敏感金黄色葡萄球菌定植，没有狗被MRSA定植。
该社区人类MRSA定植非常普遍，且单一克隆占主导，提示存在本地传播。抗生素使用也很普遍。拥挤可能部分解释了高定植率，但包括动物接触在内的大多数公认危险因素并无预测性。很少有狗携带人类葡萄球菌菌株。
