Arslan Mihriban, Ipekci Suleyman Hilmi, Kebapcilar Levent, Dogan Dede Nesrin, Kurban Sevil, Erbay Ekrem, Gonen Mustafa Sait
Department of Internal Medicine, Develi State Hospital, 38400 Kayseri, Turkey.
Division of Endocrinology and Metabolism, Faculty of Medicine, Selcuk University, 42250 Konya, Turkey.
Int Sch Res Notices. 2014 Oct 21;2014:820387. doi: 10.1155/2014/820387. eCollection 2014.
Objective. Diabetes mellitus (DM) is associated with low-grade inflammation. The benefits of regular exercise for the DM are well established, whereas less is known about the impact of aerobic exercise on malondialdehyde (MDA) and tumor necrosis factor-alpha (TNF-α) in the DM. Methods. We randomised 64 participants, who do not exercise regularly, without any diabetic chronic complications in parallel to 12 weeks of aerobic exercise (three times per week, n = 31) and no exercise (control; n = 33). Plasma levels of soluble TNF-α and MDA levels were measured before-after physical training programme and control group. Results. Sixty-four patients with type 2 diabetes mellitus were analysed. When comparing the two groups of patients with age, gender, hemoglobin A1c (HbA1c) levels, lipid profile, waist circumference, body mass index (BMI) and class of treatment for diabetes were not different between groups. While soluble TNF-α remained essentially unaffected by physical training, plasma concentrations of MDA markedly decreased (P < 0.05); physical training also decreased body weight, waist circumference, and blood pressure (P < 0.05). Conclusion. Exercise training favorably affected body weight, waist circumference, and blood pressure. A three-weekly, 12-week, aerobic-training programme, without a concomitant weight loss diet, was associated with significant decrease in MDA levels in type 2 diabetic individuals.
目的。糖尿病（DM）与低度炎症相关。规律运动对糖尿病的益处已得到充分证实，而有氧运动对糖尿病患者丙二醛（MDA）和肿瘤坏死因子-α（TNF-α）的影响则知之甚少。方法。我们将64名不经常运动且无任何糖尿病慢性并发症的参与者随机分为两组，一组进行为期12周的有氧运动（每周三次，n = 31），另一组不运动（对照组；n = 33）。在体育训练计划前后及对照组测量血浆可溶性TNF-α水平和MDA水平。结果。对64例2型糖尿病患者进行了分析。比较两组患者的年龄、性别、糖化血红蛋白（HbA1c）水平、血脂谱、腰围、体重指数（BMI）和糖尿病治疗类别，两组之间无差异。虽然可溶性TNF-α基本上不受体育训练的影响，但血浆MDA浓度显著降低（P < 0.05）；体育训练还降低了体重、腰围和血压（P < 0.05）。结论。运动训练对体重、腰围和血压有积极影响。一项为期12周、每周三次的有氧运动训练计划，在未同时进行减肥饮食的情况下，与2型糖尿病个体的MDA水平显著降低相关。
