• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

羟基磷灰石对临界尺寸缺损的影响。

Effect of hydroxyapatite on critical-sized defect.

作者信息

Kim Ryoe-Woon, Kim Ji-Hyoung, Moon Seong-Yong

机构信息

Graduate School of Dentistry, Chosun University, Gwangju, South Korea.

Department of Oral and Maxillofacial Surgery, School of Dentistry, Chosun University, 309, Pilmun-daero, Dong-gu, 501-759 Gwangju, South Korea.

出版信息

Maxillofac Plast Reconstr Surg. 2016 Jul 5;38(1):26. doi: 10.1186/s40902-016-0072-2. eCollection 2016 Dec.

DOI:10.1186/s40902-016-0072-2
PMID:27441185
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4932121/
Abstract

BACKGROUND

Xenologous or synthetic graft materials are commonly used as an alternative for autografts for guided bone regeneration. The purpose of this study was to evaluate effectiveness of carbonate apatite on the critical-size bone defect of rat's calvarium.

METHODS

Thirty-six critical-size defects were created on 18 adult male Sprague-Dawley rat calvaria under general anesthesia. Calvarial bones were grinded with 8 mm in daimeter bilaterally and then filled with (1) no grafts (control,  = 10 defects), (2) bovine bone mineral (Bio-Oss®, Geistlich Pharma Ag. Swiss,  = 11 defects), and (3) hydroxyapatite (Bongros®, Bio@ Inc., Seongnam, Korea,  = 15 defects). At 4 and 8 weeks after surgery, the rats were sacrificed and all samples were processed for histological and histomorphometric analysis.

RESULTS

At 4 weeks after surgery, group 3 (42.90 ± 9.33 %) showed a significant difference ( < 0.05) compared to the control (30.50 ± 6.05 %) and group 2 (28.53 ± 8.62 %). At 8 weeks after surgery, group 1 (50.21 ± 6.23 %), group 2 (54.12 ± 10.54 %), and group 3 (50.92 ± 6.05 %) showed no significant difference in the new bone formation.

CONCLUSIONS

Bongros®-HA was thought to be the available material for regenerating the new bone formation.

摘要

背景

异种或合成移植材料通常用作引导骨再生的自体移植替代物。本研究的目的是评估碳酸磷灰石对大鼠颅骨临界尺寸骨缺损的有效性。

方法

在全身麻醉下，于18只成年雄性Sprague-Dawley大鼠颅骨上制造36个临界尺寸缺损。将颅骨两侧磨出直径8毫米的缺损，然后分别填充：（1）不植入移植物（对照组，=10个缺损），（2）牛骨矿物质（Bio-Oss®，Geistlich Pharma Ag. Swiss，=11个缺损），以及（3）羟基磷灰石（Bongros®，Bio@ Inc.，韩国城南，=15个缺损）。术后4周和8周，处死大鼠，所有样本进行组织学和组织形态计量学分析。

结果

术后4周，第3组（42.90±9.33%）与对照组（30.50±6.05%）和第2组（28.53±8.62%）相比有显著差异（<0.05）。术后8周，第1组（50.21±6.23%）、第2组（54.12±10.54%）和第3组（50.92±6.05%）在新骨形成方面无显著差异。

结论

Bongros®-HA被认为是促进新骨形成的可用材料。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/334c/5126902/6969de95f111/40902_2016_72_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/334c/5126902/6602d1395e14/40902_2016_72_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/334c/5126902/f7b7f436222a/40902_2016_72_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/334c/5126902/492eda5551ef/40902_2016_72_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/334c/5126902/0a539ba41fdb/40902_2016_72_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/334c/5126902/dbef38e12e6d/40902_2016_72_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/334c/5126902/6969de95f111/40902_2016_72_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/334c/5126902/6602d1395e14/40902_2016_72_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/334c/5126902/f7b7f436222a/40902_2016_72_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/334c/5126902/492eda5551ef/40902_2016_72_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/334c/5126902/0a539ba41fdb/40902_2016_72_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/334c/5126902/dbef38e12e6d/40902_2016_72_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/334c/5126902/6969de95f111/40902_2016_72_Fig6_HTML.jpg

相似文献

1
Effect of hydroxyapatite on critical-sized defect.羟基磷灰石对临界尺寸缺损的影响。
Maxillofac Plast Reconstr Surg. 2016 Jul 5;38(1):26. doi: 10.1186/s40902-016-0072-2. eCollection 2016 Dec.
2
New nano-hydroxyapatite in bone defect regeneration: A histological study in rats.新型纳米羟基磷灰石在骨缺损再生中的应用：大鼠组织学研究
Ann Anat. 2017 Sep;213:83-90. doi: 10.1016/j.aanat.2017.05.010. Epub 2017 Jun 24.
3
The comparative effectiveness of demineralized bone matrix, beta-tricalcium phosphate, and bovine-derived anorganic bone matrix on inflammation and bone formation using a paired calvarial defect model in rats.使用大鼠颅骨配对缺损模型比较脱矿骨基质、β-磷酸三钙和牛源无机骨基质对炎症和骨形成的有效性。
Clin Cosmet Investig Dent. 2011 Sep 29;3:69-78. doi: 10.2147/CCIDEN.S13115. Print 2011.
4
Evaluation of New Octacalcium Phosphate-Coated Xenograft in Rats Calvarial Defect Model on Bone Regeneration.新型磷酸八钙涂层异种移植物在大鼠颅骨缺损模型中对骨再生影响的评估
Materials (Basel). 2020 Oct 1;13(19):4391. doi: 10.3390/ma13194391.
5
Guided bone regeneration in calvarial critical size bony defect using a double-layer resorbable collagen membrane covering a xenograft: a histological and histomorphometric study in rats.使用覆盖异种移植物的双层可吸收胶原膜引导大鼠颅骨临界尺寸骨缺损的骨再生：一项组织学和组织形态计量学研究
Oral Maxillofac Surg. 2018 Jun;22(2):203-213. doi: 10.1007/s10006-018-0694-x. Epub 2018 Apr 14.
6
Comparison of osteogenic potential between apatite-coated poly(lactide-co-glycolide)/hydroxyapatite particulates and Bio-Oss.磷灰石涂层聚（丙交酯-共-乙交酯）/羟基磷灰石颗粒与Bio-Oss之间成骨潜力的比较。
Dent Mater J. 2008 May;27(3):368-75. doi: 10.4012/dmj.27.368.
7
Collagen type I-based recombinant peptide promotes bone regeneration in rat critical-size calvarial defects by enhancing osteoclast activity at late stages of healing.基于I型胶原蛋白的重组肽通过在愈合后期增强破骨细胞活性促进大鼠临界大小颅骨缺损的骨再生。
Regen Ther. 2023 Oct 6;24:515-527. doi: 10.1016/j.reth.2023.09.013. eCollection 2023 Dec.
8
Combined implantation of particulate dentine, plaster of Paris, and a bone xenograft (Bio-Oss) for bone regeneration in rats.联合植入颗粒状牙本质、熟石膏和骨异种移植物（Bio-Oss）促进大鼠骨再生
J Craniomaxillofac Surg. 2001 Oct;29(5):282-8. doi: 10.1054/jcms.2001.0236.
9
Systemic and local zoledronic acid treatment with hydroxyapatite bone graft: A histological and histomorphometric experimental study.唑来膦酸与羟基磷灰石骨移植的全身及局部治疗：一项组织学和组织形态计量学实验研究。
Exp Ther Med. 2016 Oct;12(4):2417-2422. doi: 10.3892/etm.2016.3685. Epub 2016 Sep 7.
10
Native Bovine Hydroxyapatite Powder, Demineralised Bone Matrix Powder, and Purified Bone Collagen Membranes Are Efficient in Repair of Critical-Sized Rat Calvarial Defects.天然牛羟基磷灰石粉末、脱矿骨基质粉末和纯化骨胶原膜对大鼠颅骨临界尺寸缺损修复有效。
Materials (Basel). 2020 Jul 31;13(15):3393. doi: 10.3390/ma13153393.

引用本文的文献

1
Impacts of ultrasonic osteotomy devices on bone regeneration and brain activity in a mouse model.超声截骨术装置对小鼠模型骨再生和脑活动的影响。
Sci Rep. 2025 Aug 29;15(1):31871. doi: 10.1038/s41598-025-16500-9.
2
Bone regeneration by a bone substitute biomaterial containing hydroxyapatite, chitosan, xanthan and graphene oxide supplemented with conditioned medium from mesenchymal stem cells.含羟基磷灰石、壳聚糖、黄原胶和氧化石墨烯的骨替代生物材料通过间充质干细胞条件培养基促进骨再生。
Acta Odontol Latinoam. 2024 Sep 30;37(2):151-161. doi: 10.54589/aol.37/2/151.
3
Osteogenic and Angiogenic Properties of a 3D-Printed Isosorbide-Based Gyroid Scaffold Manufactured via Digital Light Processing.

本文引用的文献

1
Evaluation of bone healing with eggshell-derived bone graft substitutes in rat calvaria: a pilot study.大鼠颅骨中使用蛋壳衍生骨移植替代物的骨愈合评估：一项初步研究。
J Biomed Mater Res A. 2008 Oct;87(1):203-14. doi: 10.1002/jbm.a.31768.
2
Apatite crystallites: effects of carbonate on morphology.磷灰石微晶：碳酸盐对形态的影响。
Science. 1967 Mar 17;155(3768):1409-11. doi: 10.1126/science.155.3768.1409.
3
Mechanical characterization of dense calcium phosphate bioceramics with interconnected porosity.具有相互连通孔隙率的致密磷酸钙生物陶瓷的力学特性
通过数字光处理制造的基于异山梨醇的三维打印类螺旋曲面支架的成骨和血管生成特性
Biomedicines. 2024 Mar 7;12(3):609. doi: 10.3390/biomedicines12030609.
4
Enhancing cranial defect repair in rats: investigating the effect of combining Total Flavonoids from Rhizoma Drynariae with calcium phosphate/collagen scaffolds.增强大鼠颅骨缺损修复：研究将密花骨碎补总黄酮与磷酸钙/胶原支架相结合的效果。
J Orthop Surg Res. 2023 Nov 28;18(1):903. doi: 10.1186/s13018-023-04398-w.
5
Evaluation of Bone Repair Using a New Biphasic Synthetic Bioceramic (Plenum Oss) in Critical Calvaria Defect in Rats.使用新型双相合成生物陶瓷（普莱纳姆骨）评估大鼠颅骨关键缺损的骨修复情况。
Biology (Basel). 2023 Nov 10;12(11):1417. doi: 10.3390/biology12111417.
6
Compressive Strength of Newly Developed Nonsintered Hydroxyapatite Blocks for Bone Graft Applications.用于骨移植的新型非烧结羟基磷灰石块体的抗压强度
Eur J Dent. 2024 Jul;18(3):815-819. doi: 10.1055/s-0043-1774327. Epub 2023 Nov 23.
7
Conditioned Media from Human Pulp Stem Cell Cultures Improve Bone Regeneration in Rat Calvarial Critical-Size Defects.人牙髓干细胞培养的条件培养基可改善大鼠颅骨临界尺寸缺损的骨再生。
J Funct Biomater. 2023 Jul 25;14(8):396. doi: 10.3390/jfb14080396.
8
A three-dimensional actively spreading bone repair material based on cell spheroids can facilitate the preservation of tooth extraction sockets.一种基于细胞球状体的三维主动扩散性骨修复材料可促进拔牙窝的保存。
Front Bioeng Biotechnol. 2023 Feb 27;11:1161192. doi: 10.3389/fbioe.2023.1161192. eCollection 2023.
9
Bone Regeneration of Critical-Size Calvarial Defects in Rats Using Highly Pressed Nano-Apatite/Collagen Composites.使用高压纳米磷灰石/胶原蛋白复合材料修复大鼠临界尺寸颅骨缺损的骨再生研究
Materials (Basel). 2022 May 8;15(9):3376. doi: 10.3390/ma15093376.
10
A survey on osteogenic effect of collagen-membrane derived from swim bladder in rat calvaria.鱼鳔来源胶原膜对大鼠颅骨成骨作用的研究
Dent Res J (Isfahan). 2021 Jul 19;18:55. eCollection 2021.
J Mater Sci Mater Med. 2007 Dec;18(12):2319-29. doi: 10.1007/s10856-007-3136-0. Epub 2007 Jun 14.
4
Clinical evaluation of demineralized bone allograft in a hyaluronic acid carrier for sinus lift augmentation in humans: a computed tomography and histomorphometric study.透明质酸载体中脱矿骨同种异体移植物用于人类上颌窦提升术的临床评估：计算机断层扫描和组织形态计量学研究
Clin Oral Implants Res. 2007 Apr;18(2):204-11. doi: 10.1111/j.1600-0501.2006.01303.x.
5
The mechanical properties and osteoconductivity of hydroxyapatite bone scaffolds with multi-scale porosity.具有多尺度孔隙率的羟基磷灰石骨支架的力学性能和骨传导性。
Biomaterials. 2007 Jan;28(1):45-54. doi: 10.1016/j.biomaterials.2006.08.021. Epub 2006 Sep 11.
6
Bone regeneration in standardized bone defects with autografts or bone substitutes in combination with platelet concentrate: a histologic and histomorphometric study in the mandibles of minipigs.在小型猪下颌骨中使用自体骨移植或骨替代物联合血小板浓缩物修复标准化骨缺损的组织学和组织形态计量学研究
Int J Oral Maxillofac Implants. 2005 Sep-Oct;20(5):703-12.
7
Analysis of rat calvaria defects implanted with a platelet-rich plasma preparation: histologic and histometric observations.富含血小板血浆制剂植入大鼠颅骨缺损的分析：组织学和组织计量学观察
J Clin Periodontol. 2005 Sep;32(9):966-72. doi: 10.1111/j.1600-051X.2005.00772.x.
8
Current state of the art of biphasic calcium phosphate bioceramics.双相磷酸钙生物陶瓷的当前技术水平
J Mater Sci Mater Med. 2003 Mar;14(3):195-200. doi: 10.1023/a:1022842404495.
9
Effect of GBR in combination with deproteinized bovine bone mineral and/or enamel matrix proteins on the healing of critical-size defects.引导骨再生联合脱蛋白牛骨矿物质和/或釉基质蛋白对临界尺寸骨缺损愈合的影响
Clin Oral Implants Res. 2004 Feb;15(1):101-11. doi: 10.1111/j.1600-0501.2004.00986.x.
10
Bone regeneration graft materials.骨再生移植材料
J Oral Implantol. 2002;28(6):290-4. doi: 10.1563/1548-1336(2002)028<0290:BRGM>2.3.CO;2.