羟基磷灰石对临界尺寸缺损的影响。
Effect of hydroxyapatite on critical-sized defect.
作者信息
Kim Ryoe-Woon, Kim Ji-Hyoung, Moon Seong-Yong
机构信息
Graduate School of Dentistry, Chosun University, Gwangju, South Korea.
Department of Oral and Maxillofacial Surgery, School of Dentistry, Chosun University, 309, Pilmun-daero, Dong-gu, 501-759 Gwangju, South Korea.
出版信息
Maxillofac Plast Reconstr Surg. 2016 Jul 5;38(1):26. doi: 10.1186/s40902-016-0072-2. eCollection 2016 Dec.
BACKGROUND
Xenologous or synthetic graft materials are commonly used as an alternative for autografts for guided bone regeneration. The purpose of this study was to evaluate effectiveness of carbonate apatite on the critical-size bone defect of rat's calvarium.
METHODS
Thirty-six critical-size defects were created on 18 adult male Sprague-Dawley rat calvaria under general anesthesia. Calvarial bones were grinded with 8 mm in daimeter bilaterally and then filled with (1) no grafts (control, = 10 defects), (2) bovine bone mineral (Bio-Oss®, Geistlich Pharma Ag. Swiss, = 11 defects), and (3) hydroxyapatite (Bongros®, Bio@ Inc., Seongnam, Korea, = 15 defects). At 4 and 8 weeks after surgery, the rats were sacrificed and all samples were processed for histological and histomorphometric analysis.
RESULTS
At 4 weeks after surgery, group 3 (42.90 ± 9.33 %) showed a significant difference ( < 0.05) compared to the control (30.50 ± 6.05 %) and group 2 (28.53 ± 8.62 %). At 8 weeks after surgery, group 1 (50.21 ± 6.23 %), group 2 (54.12 ± 10.54 %), and group 3 (50.92 ± 6.05 %) showed no significant difference in the new bone formation.
CONCLUSIONS
Bongros®-HA was thought to be the available material for regenerating the new bone formation.
背景
异种或合成移植材料通常用作引导骨再生的自体移植替代物。本研究的目的是评估碳酸磷灰石对大鼠颅骨临界尺寸骨缺损的有效性。
方法
在全身麻醉下，于18只成年雄性Sprague-Dawley大鼠颅骨上制造36个临界尺寸缺损。将颅骨两侧磨出直径8毫米的缺损，然后分别填充：（1）不植入移植物（对照组，=10个缺损），（2）牛骨矿物质（Bio-Oss®，Geistlich Pharma Ag. Swiss，=11个缺损），以及（3）羟基磷灰石（Bongros®，Bio@ Inc.，韩国城南，=15个缺损）。术后4周和8周，处死大鼠，所有样本进行组织学和组织形态计量学分析。
结果
术后4周，第3组（42.90±9.33%）与对照组（30.50±6.05%）和第2组（28.53±8.62%）相比有显著差异（<0.05）。术后8周，第1组（50.21±6.23%）、第2组（54.12±10.54%）和第3组（50.92±6.05%）在新骨形成方面无显著差异。
结论
Bongros®-HA被认为是促进新骨形成的可用材料。
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