Jung Yoona, Kim Won-Hyeon, Lee Sung-Ho, Ju Kyung Won, Jang Eun-Hee, Kim Sung-O, Kim Bongju, Lee Jong-Ho
Clinical Translational Research Center for Dental Science, Seoul National University Dental Hospital, Seoul 03080, Korea.
Graduate School Department of Dental Science, Seoul National University, Seoul 03080, Korea.
Materials (Basel). 2020 Oct 1;13(19):4391. doi: 10.3390/ma13194391.
Bone graft material is essential for satisfactory and sufficient bone growth which leads to a successful implant procedure. It is classified into autogenous bone, allobone, xenobone and alloplastic materials. Among them, it has been reported that heterogeneous bone graft material has a porous microstructure that increases blood vessels and bone formation, and shows faster bone formation than other types of bone graft materials. We observed new bone tissue formation and bone remodeling using Ti-oss (Chiyewon Co., Ltd., Guri, Korea), a heterologous bone graft material. Using a Sprague-Dawley rat calvarial defect model to evaluate the bone healing effect of biomaterials, the efficacy of the newly developed xenograft Ti-oss and Bio-Oss (Geistilch Pharma AG, Wolhusen, Switzerland). The experimental animals were sacrificed at 8 and 12 weeks after surgery for each group and the experimental site was extracted. The average new bone area for the Ti-oss experimental group at 8 weeks was 17.6%. The remaining graft material was 22.7% for the experimental group. The average new bone area for the Ti-oss group was 24.3% at 12 weeks. The remaining graft material was 22.8% for the experimental group. It can be evaluated that the new bone-forming ability of Ti-oss with octacalcium phosphate (OCP) has the bone-forming ability corresponding to the conventional products.
骨移植材料对于实现令人满意且充分的骨生长至关重要，而这会带来成功的种植手术。它可分为自体骨、同种异体骨、异种骨和人工合成材料。其中，据报道异种骨移植材料具有多孔微结构，可增加血管和骨形成，并且比其他类型的骨移植材料显示出更快的骨形成。我们使用一种异种骨移植材料Ti-oss（韩国九里市Chiyewon有限公司）观察了新骨组织形成和骨重塑。利用Sprague-Dawley大鼠颅骨缺损模型来评估生物材料的骨愈合效果、新开发的异种移植物Ti-oss和Bio-Oss（瑞士沃尔胡森市Geistilch制药公司）的功效。每组在手术后8周和12周处死实验动物，并提取实验部位。Ti-oss实验组在8周时的平均新骨面积为17.6%。实验组剩余的移植材料为22.7%。Ti-oss组在12周时的平均新骨面积为24.3%。实验组剩余的移植材料为22.8%。可以评估，含磷酸八钙（OCP）的Ti-oss的新骨形成能力具有与传统产品相当的骨形成能力。
