Bilateral carcinoma in situ of testis in infertile man.

Abnormal seminiferous epithelium with atypical germ cells was studied in 2 previous cases. Embryonal carcinoma occurred within four and one-half years of testicular biopsy. Herein is reported another case of bilateral carcinoma in situ of the testis, presenting abnormal germinal morphology and infertility. The abnormal cells differed considerably from normal spermatogonia, presenting an increased diameter and dense chromatin masses. Apparently normal tubules were also present with normal spermatogenesis. Serum gonadotropins and chromosome study were normal. After bilateral biopsy patient was submitted to a right orchiectomy and left varicocelectomy.