Netto N R
Urology. 1985 Jun;25(6):601-4. doi: 10.1016/0090-4295(85)90289-4.
Abnormal seminiferous epithelium with atypical germ cells was studied in 2 previous cases. Embryonal carcinoma occurred within four and one-half years of testicular biopsy. Herein is reported another case of bilateral carcinoma in situ of the testis, presenting abnormal germinal morphology and infertility. The abnormal cells differed considerably from normal spermatogonia, presenting an increased diameter and dense chromatin masses. Apparently normal tubules were also present with normal spermatogenesis. Serum gonadotropins and chromosome study were normal. After bilateral biopsy patient was submitted to a right orchiectomy and left varicocelectomy.
在之前的2例病例中研究了伴有非典型生殖细胞的异常生精上皮。胚胎癌在睾丸活检后四年半内发生。本文报道了另一例睾丸双侧原位癌病例，表现为生精形态异常和不育。异常细胞与正常精原细胞有很大差异，直径增大且染色质团块致密。明显正常的小管也存在正常的精子发生。血清促性腺激素和染色体研究正常。双侧活检后，患者接受了右侧睾丸切除术和左侧精索静脉曲张切除术。
