阻塞性黄疸肝脏组织中的石胆酸盐。
Lithocholate in liver tissue with obstructive jaundice.
作者信息
Yanagisawa J, Nagai M, Hirano Y, Fujii T, Nakayama F
机构信息
First Department of Surgery, Kyushu University Faculty of Medicine, Fukuoka, Japan.
出版信息
Gastroenterol Jpn. 1989 Apr;24(2):156-8. doi: 10.1007/BF02774190.
The existence of tissue-bound lithocholate in liver tissue was first suggested by Nair et al. (Lipids 1988;12:922-929). Since lithocholate is well known to be cholestatic, we investigated whether tissue-bound lithocholate, if present, can be correlated to liver dysfunction in obstructive jaundice. Tissue-bound lithocholate in liver tissues of 7 patients with obstructive jaundice was analyzed using gas chromatography-mass spectrometry-selected ion monitoring. We found no accumulation of lithocholate, including tissue-bound form, indicating that the role of lithocholate in inducing hepatic dysfunction in obstructive jaundice is minimal, if any.
奈尔等人（《脂质》，1988年；12卷：922 - 929页）首次提出肝脏组织中存在组织结合型石胆酸。由于众所周知石胆酸具有胆汁淤积作用，我们研究了如果存在组织结合型石胆酸，它是否与梗阻性黄疸中的肝功能障碍相关。使用气相色谱 - 质谱 - 选择离子监测法分析了7例梗阻性黄疸患者肝脏组织中的组织结合型石胆酸。我们发现石胆酸没有蓄积，包括组织结合型，这表明石胆酸在梗阻性黄疸中诱导肝功能障碍的作用即使有也是极小的。
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