评估玫瑰痤疮患者心血管疾病的风险。

Assessment of the risk of cardiovascular disease in patients with rosacea.

机构信息

Department of Dermatology and Allergy, Herlev and Gentofte University Hospital, University of Copenhagen, Hellerup, Denmark; Department of Cardiology, Herlev and Gentofte University Hospital, University of Copenhagen, Hellerup, Denmark.

Department of Cardiology, Herlev and Gentofte University Hospital, University of Copenhagen, Hellerup, Denmark.

出版信息

J Am Acad Dermatol. 2016 Aug;75(2):336-9. doi: 10.1016/j.jaad.2016.02.1158.

DOI:10.1016/j.jaad.2016.02.1158

PMID:27444070

Abstract

BACKGROUND

Recent studies have shown a higher prevalence of cardiovascular (CV) risk factors in patients with rosacea. However, it remains unknown whether rosacea represents an independent CV risk factor.

OBJECTIVE

We evaluated the risk of myocardial infarction, stroke, CV death, major adverse CV events, and all-cause mortality, respectively.

METHODS

Between January 1, 1997, and December 31, 2012, a total of 4948 patients with rosacea were identified and matched with 23,823 control subjects. We used Poisson regression to calculate incidence rate ratios.

RESULTS

Adjusted incidence rate ratios were 0.75 (95% confidence intervals [CI] 0.57-1.00) for myocardial infarction, 1.08 (95% CI 0.86-1.35) for ischemic stroke, 1.01 (95% CI 0.61-1.67) for hemorrhagic stroke, 0.99 (95% CI 0.80-1.24) for CV death, 0.99 (95% CI 0.86-1.15) for major adverse CV events, and 0.95 (95% CI 0.85-1.06) for all-cause mortality.

LIMITATIONS

We were unable to distinguish between the different subtypes and severities of rosacea.

CONCLUSIONS

In this population-based study, rosacea was not associated with increased risk of adverse CV outcomes or death.

摘要

背景

最近的研究表明，酒渣鼻患者的心血管（CV）危险因素患病率较高。然而，酒渣鼻是否代表独立的 CV 危险因素仍不清楚。

目的

我们分别评估了心肌梗死、中风、CV 死亡、主要不良 CV 事件和全因死亡率的风险。

方法

1997 年 1 月 1 日至 2012 年 12 月 31 日期间，共确定了 4948 例酒渣鼻患者，并与 23823 例对照患者进行匹配。我们使用泊松回归计算发病率比值。

结果

调整后的发病率比值分别为心肌梗死 0.75（95%置信区间 [CI] 0.57-1.00）、缺血性中风 1.08（95% CI 0.86-1.35）、出血性中风 1.01（95% CI 0.61-1.67）、CV 死亡 0.99（95% CI 0.80-1.24）、主要不良 CV 事件 0.99（95% CI 0.86-1.15）和全因死亡率 0.95（95% CI 0.85-1.06）。