Schindler R
Nierenzentrum Zehlendorf, Fischerhüttenstr. 111, 14163, Berlin, Deutschland.
Z Gerontol Geriatr. 2016 Aug;49(6):483-7. doi: 10.1007/s00391-016-1110-5. Epub 2016 Jul 21.
Renal function in humans declines with old age. Currently, the normal range for renal function is not differentiated by age but uniformly given, which has evoked criticism. The symptoms of high-grade impairment of renal function are nonspecific. The current data situation does not support early initiation of dialysis: on the contrary, initiation of dialysis should be decided from clinical aspects and not according to the values for the glomerular filtration rate (GFR). Elderly patients should be offered peritoneal dialysis (PD) as well as hemodialysis (HD), which can be performed either at home (PD) or at a dialysis center (HD or PD). Patients and their relatives should be presented with all available information on both therapy options but there are also conservative, palliative therapy options for the very old or for those with a high number of comorbidities. The decision for therapy should be individualized and tailored for each patient. The planning of kidney replacement therapy should be carried out well in advance. A multidisciplinary team should discuss possible barriers to one or the other treatment option and provide assistance for implementation of the individual optimal therapy. In some cases a home-based assisted PD can be a sensible option.
人类的肾功能会随着年龄增长而衰退。目前,肾功能的正常范围并未按年龄区分,而是统一给出,这引发了批评。肾功能高度受损的症状不具有特异性。当前的数据情况不支持早期开始透析:相反,透析的开始应从临床角度决定,而非依据肾小球滤过率(GFR)的值。老年患者应接受腹膜透析(PD)以及血液透析(HD),腹膜透析可在家中进行,血液透析可在透析中心进行(HD或PD)。应向患者及其亲属提供关于这两种治疗方案的所有可用信息,但对于高龄患者或患有多种合并症的患者,也有保守的姑息治疗方案。治疗决策应个体化,为每位患者量身定制。肾脏替代治疗的规划应提前做好。多学科团队应讨论每种治疗方案可能存在的障碍,并为实施个体最佳治疗提供帮助。在某些情况下,居家辅助腹膜透析可能是一个明智的选择。