Poza Guedes Paloma, Sánchez Machín Inmaculada, Matheu Víctor, Iraola Víctor, González Pérez Ruperto
Allergy Department, Hospital del Tórax, HUNS La Candelaria, 38320 Santa Cruz de Tenerife, Spain.
Department of Clinical Sciences-Division IV, Lund University, 22100 Lund, Sweden.
Can Respir J. 2016;2016:5782317. doi: 10.1155/2016/5782317. Epub 2016 Jun 28.
Mites can sensitize and induce atopic disease in predisposed individuals and are an important deteriorating factor in patients with allergic rhinitis, asthma, and atopic dermatitis. Although Pyroglyphidae mites have been extensively studied, very scarce reports are available on Cheyletidae spp. especially regarding human respiratory pathology. The main objective of the present study is to investigate the clinical role of this predator mite (Cheyletus eruditus) as a respiratory antigen in a selected sensitized human population. Fifty-two adult patients were recruited from the outpatient allergy clinic to assess their eligibility for the study. The thirty-seven subjects with persistent allergic rhinitis (PAR) who fulfilled the ARIA criteria had a positive IgE response confirmed by skin prick test (SPT) to C. eruditus. Only those individuals (37/47) with a positive SPT to C. eruditus showed a positive nasal provocation test (NPT), while 10 patients with nonallergic mild-to-moderate persistent rhinitis, control group, had a negative NPT with C. eruditus. The present paper describes a new role for the predator mite Cheyletus eruditus as a respiratory allergen in a selected subset of patients in a subtropical environment afflicted with persistent nonoccupational allergic rhinitis.
螨虫可使易感个体致敏并诱发特应性疾病，是变应性鼻炎、哮喘和特应性皮炎患者病情恶化的重要因素。虽然粉螨科螨虫已得到广泛研究，但关于肉食螨科物种的报道却非常稀少，尤其是在人类呼吸道病理学方面。本研究的主要目的是调查这种捕食性螨虫（仓廪肉食螨）作为呼吸道抗原在选定的致敏人群中的临床作用。从门诊过敏诊所招募了52名成年患者，以评估他们是否符合研究条件。37名符合变应性鼻炎和哮喘的全球策略（ARIA）标准的持续性变应性鼻炎（PAR）患者，经皮肤点刺试验（SPT）证实对仓廪肉食螨有阳性IgE反应。只有那些对仓廪肉食螨SPT呈阳性的个体（37/47）鼻激发试验（NPT）呈阳性，而10名非变应性轻至中度持续性鼻炎患者作为对照组，对仓廪肉食螨的NPT为阴性。本文描述了捕食性螨虫仓廪肉食螨在亚热带环境中患有持续性非职业性变应性鼻炎的特定患者亚组中作为呼吸道变应原的新作用。
