Constans Annabelle, Pin-Barre Caroline, Temprado Jean-Jacques, Decherchi Patrick, Laurin Jérôme
Aix-Marseille Université, CNRS, ISM, UMR 7287 Marseille, France.
Aix-Marseille Université, CNRS, ISM, UMR 7287Marseille, France; Université Nice Sophia Antipolis, LAMHESS, UPRES EA 6309Nice, France.
Front Aging Neurosci. 2016 Jun 30;8:164. doi: 10.3389/fnagi.2016.00164. eCollection 2016.
Stroke often aggravated age-related cognitive impairments that strongly affect several aspects of quality of life. However, few studies are, to date, focused on rehabilitation strategies that could improve cognition. Among possible interventions, aerobic training is well known to enhance cardiovascular and motor functions but may also induce beneficial effects on cognitive functions. To assess the effectiveness of aerobic training on cognition, it seems necessary to know whether training promotes the neuroplasticity in brain areas involved in cognitive functions. In the present review, we first explore in both human and animal how aerobic training could improve cognition after stroke by highlighting the neuroplasticity mechanisms. Then, we address the potential effect of combinations between aerobic training with other interventions, including resistance exercises and pharmacological treatments. In addition, we postulate that classic recommendations for aerobic training need to be reconsidered to target both cognition and motor recovery because the current guidelines are only focused on cardiovascular and motor recovery. Finally, methodological limitations of training programs and cognitive function assessment are also developed in this review to clarify their effectiveness in stroke patients.
中风常常会加重与年龄相关的认知障碍，而这种障碍会严重影响生活质量的多个方面。然而，迄今为止，很少有研究关注能够改善认知的康复策略。在可能的干预措施中，有氧训练众所周知可以增强心血管和运动功能，但也可能对认知功能产生有益影响。为了评估有氧训练对认知的有效性，了解训练是否能促进参与认知功能的脑区的神经可塑性似乎很有必要。在本综述中，我们首先通过强调神经可塑性机制，探讨在人类和动物中，有氧训练如何改善中风后的认知。然后，我们讨论有氧训练与其他干预措施（包括抗阻运动和药物治疗）相结合的潜在效果。此外，我们推测，由于目前的指南仅关注心血管和运动恢复，因此需要重新考虑有氧训练的经典建议，以同时针对认知和运动恢复。最后，本综述还阐述了训练方案和认知功能评估的方法学局限性，以阐明它们在中风患者中的有效性。
