Paquissi Feliciano Chanana
Department of Medicine, Clínica Girassol, Luanda, Angola.
J Biomark. 2016;2016:8160393. doi: 10.1155/2016/8160393. Epub 2016 Jul 3.
Atrial fibrillation (AF) is the most common arrhythmia and is responsible for significant disease burden worldwide. Current evidence has suggested that systemic inflammatory response plays a crucial role in the initiation, maintenance, and progression of AF. So, recent efforts have been directed in search of measurable inflammatory biomarkers as additional tools in severity and prognosis assessment of AF. A simple, and easily obtainable, inflammatory marker is the neutrophil-lymphocyte ratio (NLR), which has shown good performance in preliminary studies as a potential prognostic biomarker in patients with AF. In this work, we performed a thorough review of clinical studies that evaluated the role of C-reactive protein (CRP), interleukin-6 (IL-6), and NLR as predictors of outcomes in AF. We gave a particular emphasis on the NLR because it is a simpler, widely available, and inexpensive biomarker.
心房颤动（AF）是最常见的心律失常，在全球范围内造成了重大的疾病负担。目前的证据表明，全身炎症反应在房颤的发生、维持和进展中起着关键作用。因此，最近的研究致力于寻找可测量的炎症生物标志物，作为评估房颤严重程度和预后的额外工具。一种简单且易于获取的炎症标志物是中性粒细胞与淋巴细胞比值（NLR），在初步研究中，它作为房颤患者潜在的预后生物标志物表现良好。在这项工作中，我们对评估C反应蛋白（CRP）、白细胞介素-6（IL-6）和NLR作为房颤预后预测指标作用的临床研究进行了全面综述。我们特别强调了NLR，因为它是一种更简单、广泛可用且廉价的生物标志物。
