Negreva Mariya, Georgiev Svetoslav, Prodanova Krasimira
First Clinic of Cardiology, Varna University Hospital "St. Marina", Bulgaria.
Second Clinic of Cardiology, Varna University Hospital "St. Marina", Varna, Bulgaria.
Cardiol Res. 2016 Feb;7(1):1-8. doi: 10.14740/cr455w. Epub 2016 Feb 20.
A number of data have been accumulated on inflammation in persistent and permanent atrial fibrillation (AF). Our aim was to study the process in paroxysmal AF (PAF) by measuring plasma concentrations of high-sensitivity C-reactive protein (hs-CRP), serum amyloid A (SAA) and fibrinogen in dynamics.
The markers were investigated in 51 patients (26 males and 25 females; 59.84 ± 1.60 years) at hospital admission (baseline), 24 hours and 28 days after sinus rhythm restoration. Fifty-two controls (26 males and 26 females; 59.50 ± 1.46 years) were selected.
At baseline, hs-CRP and SAA concentrations were higher in patients (8.12 ± 0.82 vs. 5.57 ± 0.21 mg/L, P = 0.003; 16.04 ± 0.93 vs. 5.12 ± 0.23 ng/mL, P < 0.001, respectively) and these changes persisted 24 hours after sinus rhythm restoration (8.16 ± 0.71 vs. 5.57 ± 0.21 mg/L, P < 0.001; 12.99 ± 0.75 vs. 5.12 ± 0.23 ng/mL, P < 0.001, respectively). On the 28th day, no significant difference was measured (5.42 ± 0.29 vs. 5.57 ± 0.21 mg/L, P = 0.68; 5.89 ± 0.38 vs. 5.12 ± 0.23 ng/mL, P = 0.08, respectively). At any measurement, fibrinogen levels did not differ between patients and controls (3.30 ± 0.17 vs. 3.22 ± 0.11 g/L, P = 0.70; 3.32 ± 0.11 vs. 3.22 ± 0.11 g/L, P = 0.52; 3.24 ± 0.13 vs. 3.22 ± 0.11 g/L, P = 0.90, respectively).
PAF is associated with dynamics in hs-CRP and SAA plasma levels. The results suggest that inflammation is closely related to the arrhythmia initiation.
关于持续性和永久性心房颤动（AF）中的炎症，已有大量数据积累。我们的目的是通过动态测量高敏C反应蛋白（hs-CRP）、血清淀粉样蛋白A（SAA）和纤维蛋白原的血浆浓度，研究阵发性AF（PAF）中的这一过程。
在51例患者（26例男性和25例女性；59.84±1.60岁）入院时（基线）、恢复窦性心律后24小时和28天对这些标志物进行研究。选取52例对照者（26例男性和26例女性；59.50±1.46岁）。
基线时，患者的hs-CRP和SAA浓度较高（分别为8.12±0.82 vs. 5.57±0.21mg/L，P = 0.003；16.04±0.93 vs. 5.12±0.23ng/mL，P<0.001），且这些变化在恢复窦性心律后24小时持续存在（分别为8.16±0.71 vs. 5.57±0.21mg/L，P<0.001；12.99±0.75 vs. 5.12±0.23ng/mL，P<0.001）。在第28天，未测得显著差异（分别为5.42±0.29 vs. 5.57±0.21mg/L，P = 0.68；5.89±0.38 vs. 5.12±0.23ng/mL，P = 0.08）。在任何测量时，患者和对照者之间的纤维蛋白原水平均无差异（分别为3.30±0.17 vs. 3.22±0.11g/L，P = 0.70；3.32±0.11 vs. 3.22±0.11g/L，P = 0.52；3.24±0.13 vs. 3.22±0.11g/L，P = 0.90）。
PAF与hs-CRP和SAA血浆水平的动态变化有关。结果表明炎症与心律失常的起始密切相关。
