基于蚀斑减少中和试验比较血凝抑制试验和IgG酶联免疫吸附测定法对登革热原发性和继发性感染的分类情况
Comparison of the Hemagglutination Inhibition Test and IgG ELISA in Categorizing Primary and Secondary Dengue Infections Based on the Plaque Reduction Neutralization Test.
作者信息
Lukman Nurhayati, Salim Gustiani, Kosasih Herman, Susanto Nugroho Harry, Parwati Ida, Fitri Silvita, Alisjahbana Bachti, Widjaja Susana, Williams Maya
机构信息
Indonesia Research Partnership on Infectious Diseases (INA-RESPOND), Jalan Percetakan Negara No. 29, Jakarta 10560, Indonesia; U.S. Naval Medical Research Unit No. 2, Jakarta 10560, Indonesia.
U.S. Naval Medical Research Unit No. 2, Jakarta 10560, Indonesia.
出版信息
Biomed Res Int. 2016;2016:5253842. doi: 10.1155/2016/5253842. Epub 2016 Jun 30.
Abstract
Secondary dengue infection by heterotypic serotypes is associated with severe manifestations of disease, that is, dengue hemorrhagic fever (DHF) and dengue shock syndrome (DSS). The World Health Organization (WHO) has recommended criteria based on the hemagglutination inhibition (HI) test to distinguish between primary and secondary dengue infections. Since the HI test has practical limitations and disadvantages, we evaluated the accuracy of WHO HI criteria and compared it with criteria based on an IgG enzyme-linked immunosorbent assay (ELISA) using a plaque reduction neutralization test (PRNT) as the gold standard. Both WHO HI criteria and IgG ELISA criteria performed strongly (16/16) in determining primary infection. However, to determine secondary infection, the IgG ELISA criteria performed better (72/73) compared to the WHO HI criteria (23/73).
摘要
异型血清型引起的登革热二次感染与疾病的严重表现相关，即登革出血热（DHF）和登革休克综合征（DSS）。世界卫生组织（WHO）已推荐基于血凝抑制（HI）试验的标准来区分原发性和继发性登革热感染。由于HI试验存在实际局限性和缺点，我们评估了WHO HI标准的准确性，并将其与基于IgG酶联免疫吸附测定（ELISA）的标准进行比较，以蚀斑减少中和试验（PRNT）作为金标准。WHO HI标准和IgG ELISA标准在确定原发性感染方面表现都很强（16/16）。然而，在确定继发性感染方面，与WHO HI标准（23/73）相比，IgG ELISA标准表现更好（72/73）。
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