Qosa H, Mohamed L A, Alqahtani S, Abuasal B S, Hill R A, Kaddoumi A
Department of Basic Pharmaceutical Sciences, School of Pharmacy, University of Louisiana at Monroe, Monroe, Louisiana, USA.
Clin Pharmacol Ther. 2016 Nov;100(5):441-453. doi: 10.1002/cpt.435. Epub 2016 Aug 27.
Membrane transport proteins have central physiological function in maintaining cerebral homeostasis. These transporters are expressed in almost all cerebral cells in which they regulate the movement of a wide range of solutes, including endogenous substrates, xenobiotic, and therapeutic drugs. Altered activity/expression of central nervous system (CNS) transporters has been implicated in the onset and progression of multiple neurological diseases. Neurological diseases are heterogeneous diseases that involve complex pathological alterations with only a few treatment options; therefore, there is a great need for the development of novel therapeutic treatments. To that end, transporters have emerged recently to be promising therapeutic targets to halt or slow the course of neurological diseases. The objective of this review is to discuss implications of transporters in neurological diseases and summarize available evidence for targeting transporters as decent therapeutic approach in the treatment of neurological diseases.
膜转运蛋白在维持脑内稳态中具有核心生理功能。这些转运体几乎在所有脑细胞中表达，它们在其中调节多种溶质的转运，包括内源性底物、外源性物质和治疗药物。中枢神经系统（CNS）转运体活性/表达的改变与多种神经疾病的发生和发展有关。神经疾病是异质性疾病，涉及复杂的病理改变且治疗选择有限；因此，迫切需要开发新的治疗方法。为此，转运体最近已成为有望阻止或减缓神经疾病进程的治疗靶点。本综述的目的是讨论转运体在神经疾病中的意义，并总结将转运体作为神经疾病治疗的合适治疗方法的现有证据。
