Mouridsen Svend Erik, Rich Bente, Isager Torben
a Centre for Child and Adolescent Psychiatry , Bispebjerg University Hospital , Copenhagen , Denmark.
b Roskilde , Denmark.
Ophthalmic Epidemiol. 2017 Oct;24(5):332-335. doi: 10.1080/09286586.2017.1291843. Epub 2017 Mar 15.
The objective of this study was to compare the prevalence and types of eye disorders in a clinical sample of 118 adult people diagnosed with infantile autism (IA) during childhood with 336 sex- and age-matched controls from the general population.
All participants were screened through the nationwide Danish National Hospital Register. The average observation time of both groups was 37.2 years, and mean age was 49.6 years, by the end of the observation period.
The overall prevalence of any eye disorder was 15.3% (18/118) in cases with IA, compared to 10.1% (34/336) in controls (p = 0.18). Refraction and accommodation disorders were significantly associated with IA: 7.6% (9/118) vs 1.2% (4/336) (p = 0.001). The rate of eye disorder was particularly high (24.5%) in those with a co-occurring profound or severe learning disability (IQ < 50).
Refraction and accommodation disorders were more frequently present in Danish adults with IA, particularly when a profound or severe learning disability was co-present. The increased prevalence of eye disorders in participants with a severe or profound learning disability, and the fact that people with IA do not necessarily realize the presence of a vision deficit, necessitates increased ophthalmological attention.
本研究的目的是比较118名童年期被诊断为婴幼儿自闭症（IA）的成年人临床样本与336名来自普通人群的性别和年龄匹配的对照组中眼部疾病的患病率和类型。
所有参与者均通过丹麦全国性的国家医院登记系统进行筛查。在观察期结束时，两组的平均观察时间为37.2年，平均年龄为49.6岁。
IA患者中任何眼部疾病的总体患病率为15.3%（18/118），而对照组为10.1%（34/336）（p = 0.18）。屈光和调节障碍与IA显著相关：7.6%（9/118）对1.2%（4/336）（p = 0.001）。同时患有严重或极重度学习障碍（智商<50）的患者眼部疾病发生率特别高（24.5%）。
屈光和调节障碍在丹麦成年IA患者中更为常见，尤其是在同时存在严重或极重度学习障碍的情况下。患有严重或极重度学习障碍的参与者中眼部疾病患病率增加，以及IA患者不一定意识到视力缺陷的存在，这使得有必要加强眼科关注。
