Halperin E C, Dosoretz D E, Goodman M, Wang C C
Br J Radiol. 1982 Sep;55(657):645-9. doi: 10.1259/0007-1285-55-657-645.
The term "lethal mid-line granuloma" does not properly reflect current knowledge that several different diseases can produce non-infectious mid-facial destruction. The disorders producing erosion of the upper aerodigestive passages are more accurately classified by clinical and histological criteria as either Wegener's or non-Wegener's causes. The non-Wegener's causes of mid-facial erosion include extranodal lymphoma, idiopathic mid-line granuloma and polymorphic reticulosis. Polymorphic reticulosis (PR) is a rare disease which is histologically identical to lymphomatoid granulomatosis (LG). The term PR has been used to describe LG localized to the upper airways. PR-LG is characterized by a remarkably polymorphic angiocentric mixed cellular infiltrate. The disease is locally invasive, has the potential for distant spread, and can cause fever, sweats and weight loss. When it is localized to the upper airways, PR-LG is potentially controllable by radiation therapy. Local symptoms at other body sites can be successfully palliated by radiation. The clinical presentation of two recent patients with PR-LG is summarized, as well as the radiotherapy employed. The pertinent literature is reviewed.
术语“致死性中线肉芽肿”并不能准确反映当前的认知，即几种不同的疾病均可导致非感染性的面部中部破坏。通过临床和组织学标准，对上呼吸道产生糜烂的疾病可更准确地分类为韦格纳（氏）病因或非韦格纳（氏）病因。面部中部糜烂的非韦格纳（氏）病因包括结外淋巴瘤、特发性中线肉芽肿和多形性网状细胞增生症。多形性网状细胞增生症（PR）是一种罕见疾病，在组织学上与淋巴瘤样肉芽肿病（LG）相同。术语PR曾用于描述局限于上呼吸道的LG。PR-LG的特征是显著多形性的血管中心性混合细胞浸润。该疾病具有局部侵袭性，有可能发生远处扩散，并可导致发热、盗汗和体重减轻。当PR-LG局限于上呼吸道时，有可能通过放射治疗加以控制。身体其他部位的局部症状可通过放射治疗成功缓解。总结了近期两名PR-LG患者的临床表现以及所采用的放射治疗方法，并对相关文献进行了综述。
